FIGURE

Fig. S2

ID

ZDB-FIG-151208-21

Publication

Jensen et al., 2015 - VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish

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Fig. S2

Differential effects of VEGF-Ba and VEGF-Aa on developmental angiogenesis in zebrafish embryos. (A) Confocal micrographs of 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled, Vegfba, and Vegfaa morpholinos. White arrows indicate brain vasculatures. Yellow arrows indicate ISVs. (Scale bar in overview, 500 µm; in brain and periphery, 50 µm.) (B) Quantification of the percentage of embryos with defective ISVs in 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled (Ctrl), Vegfba (Ba), or Vegfaa (Aa) morpholino (n = 7–14 embryos/group). ***P < 0.001. (C) Quantification of brain vessel density of 72-hpf fli1a:EGFP embryos injected with 0.6 pmol scrambled (Ctrl), Vegfba (Ba), and Vegfaa (Aa) morpholinos (n = 8–18 embryos/group). *P < 0.05; ***P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA