FIGURE

Fig. 6

ID

ZDB-FIG-150625-3

Publication

Wolman et al., 2015 - A Genome-wide Screen Identifies PAPP-AA-Mediated IGFR Signaling as a Novel Regulator of Habituation Learning

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Fig. 6

PAPP-AA Mediates Habituation through Acute Regulation of IGF Signaling

(A) Mean acoustic startle habituation percentage at 5 dpf of larvae treated with DMSO or 1 µM SC79. Treatment period (dpf) indicated below bars.

(B) Mean acoustic startle habituation percentage of 5 dpf larvae treated with 740 Y-P for 30 min prior to and during habituation assay.

(C and D) Mean acoustic startle habituation percentage after 30 min treatment with BMS-754807 or DMSO at 5 dpf (C) or 12 dpf (D). p < 0.01, p < 0.001, ANOVA with Bonferonni correction versus DMSO-treated larvae of the same genotype. N = number of larvae shown within bars. Error bars indicate SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT pappaa^p170/p170
Condition:	chemical treatment: BMS-754807
Observed In:	habituation
Stage Range:	Day 5 to Days 14-20

Phenotype Detail

Acknowledgments

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