FIGURE

Fig. 10

ID

ZDB-FIG-150615-10

Publication

Krock et al., 2014 - The Par-PrkC Polarity Complex Is Required for Cilia Growth in Zebrafish Photoreceptors

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Fig. 10

Pharmacological inhibition of PrkC activity reduces apical domain size. (A–C) Transverse cryosections of 4 dpf retinas were stained with phalloidin to label actin (red) and zpr-1 to label double cones (green). (A) DMSO-control treated larvae; (B) Larvae treated with 3 μM PrkC inhibitor; (C) Larvae treated with 3 μM control inhibitor. Sections were also counterstained with DAPI (blue). (D) Quantification of apical domain as a percentage of total photoreceptor inner segment length. All values are plotted as a percentage of n/m, as defined in the text. Control = 45%; PrkC inhibitor = 28%; non-myristoylated control inhibitor = 44%. Blue error bars indicate the mean ± standard deviation. Scale bar = 10 μm.

Expression Data

Antibody:	zpr-1
Fish:	AB/EKW
Condition:	chemical treatment: EC 2.7.11.13 (protein kinase C) inhibitor
Anatomical Term:	retinal cone cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/EKW
Condition:	chemical treatment: EC 2.7.11.13 (protein kinase C) inhibitor
Observed In:	eye photoreceptor cell apical region
Stage:	Day 4

Phenotype Detail

Acknowledgments

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