FIGURE

Fig. 2

ID

ZDB-FIG-150609-16

Publication

Bührdel et al., 2015 - In vivo characterization of human myofibrillar myopathy genes in zebrafish

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Fig. 2

Loss of MFM gene function results in a progressive motility deficiency (A–C) Spontaneous movement assay with false-colored superimposed overviews of 24 hpf control (A) and MFM morphants (B–C); Red pictures = 0 s; green pictures = 10 s. (D) Summary of voluntary movement at 24 hpf of MFM morphants. (E) Quantification of flight reaction to a touch stimulus of 72 hpf individuals. Darker gray bars indicate the effect of Morpholinos directed against non-MFM genes as controls. Asterisks indicate significance compared to the MO-control group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cryaba WT + MO1-cryabb WT + MO1-dnajb6a WT + MO1-dnajb6b WT + MO1-fhl1b WT + MO1-ldb3a WT + MO1-myot WT + MO1-plcg1 WT + MO1-pleca WT + MO1-plecb WT + MO2-bag3 WT + MO2-cmlc1 WT + MO2-desma WT + MO2-flnca WT + MO3-desmb WT + MO3-fhl1a WT + MO3-vcp WT + MO4-flncb
Knockdown Reagents:	MO1-cryaba MO1-cryabb MO1-dnajb6a MO1-dnajb6b MO1-fhl1b MO1-ldb3a MO1-myot MO1-plcg1 MO1-pleca MO1-plecb MO2-bag3 MO2-cmlc1 MO2-desma MO2-flnca MO3-desmb MO3-fhl1a MO3-vcp MO4-flncb
Observed In:	locomotion thigmotaxis whole organism
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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