FIGURE

Fig. 5

ID

ZDB-FIG-150512-5

Publication

Burgoyne et al., 2015 - Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL

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Fig. 5

PMELa MO reduces the number of cylindrical melanosomes to a greater extent than PMELb MO. (A–D) Electron micrographs highlighting melanosome morphology at 2dpf for zebrafish injected with control (A), PMELa (B), PMELb (C) and PMELa&b MOs (D). Scale bars: 1µm. (E) The PMELa&b MO resulted in a decrease in the number of melanosomes. Ctrl, control. (F) All PMEL MOs resulted in a significant loss of cylindrical melanosomes. PMELa had a greater effect on melanosome shape than the PMELb MO. Results show the mean±s.e.m. *P<0.05, **P<0.01, ***P<0.001 (Student′s t-test).

Expression Data

Expression Detail

No data available

Antibody Labeling

No data available

Phenotype Data

Fish:	WT + MO1-pmelb WT + MO2-pmela WT + MO1-pmelb + MO2-pmela
Knockdown Reagents:	MO1-pmelb MO2-pmela
Observed In:	melanosome assembly retinal pigmented epithelium melanosome
Stage:	Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Cell Sci.