FIGURE

Fig. 2

ID

ZDB-FIG-150319-20

Publication

Cheng et al., 2015 - The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis

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Fig. 2

The expression of her2 is lost in Notch-deficient embryos. (A) The expression of her2 was analyzed in mib^ta52b homozygous mutants and wild-type siblings by in situ hybridization. The stages are shown in the bottom left corner. Left and right panels are lateral views, and the middle panels are dorsal views. The arrows indicate her2 expression in the neural progenitor cells. (B) DAPT treatment was performed at different time points, and the embryos were harvested at different stages as indicated, showing that DAPT treatment caused a downregulation of her2 expression.

Expression Data

Gene:	her2
Fish:	TU WT mib1^ta52b/ta52b
Condition:	chemical treatment: DAPT
Anatomical Terms:	central nervous system neuroectoderm segmental plate
Stage Range:	75%-epiboly to Prim-5

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
her2	TU	control	75%-epiboly	neuroectoderm	ISH
her2	TU	control	Bud	neuroectoderm	ISH
her2	TU	control	Bud	segmental plate	ISH
her2	TU	control	Prim-5	central nervous system	ISH
her2	TU	chemical treatment: DAPT	75%-epiboly	neuroectoderm	ISH
her2	TU	chemical treatment: DAPT	Bud	neuroectoderm	ISH
her2	TU	chemical treatment: DAPT	Bud	segmental plate	ISH
her2	TU	chemical treatment: DAPT	Prim-5	central nervous system	ISH
her2	WT	standard conditions	75%-epiboly	neuroectoderm	ISH
her2	WT	standard conditions	Bud	neuroectoderm	ISH

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Antibody Labeling

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Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 397(1), Cheng, Y.C., Chiang, M.C., Shih, H.Y., Ma, T.L., Yeh, T.H., Huang, Y.C., Lin, C.Y., Lin, S.J., The transcription factor hairy/E(spl)-related 2 induces proliferation of neural progenitors and regulates neurogenesis and gliogenesis, 116-28, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.