FIGURE

Fig. 3

ID

ZDB-FIG-141007-104

Publication

Cardozo et al., 2014 - Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle

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Fig. 3

(a–d) Lateral views of control or cdon^ATG morphants treated with DMSO (vehicle) or cyclopamine from 90% epiboly and analysed with ISH for pax2.1 expression at 28 hpf. Blocking Hh signalling abolished pax2.1 expression in the optic stalk in wt embryos (c). In cdon^ATG morphants, cyclopamine treatment counteracts the expansion of pax2.1 overexpression observed in cdon^ATGMO injected embryos (a,b,d). The lens and the body are outlined with black and white dashed lines in (a–d). Arrows indicate the extent of the pax2.1 expression in the optic stalk. DMSO, dimethyl sulphoxide; MHB, midbrain–hindbrain boundary; oc, optic cup; os, optic stalk. Scale bar, 100 μm.

Expression Data

Gene:	pax2a
Fish:	WT WT + MO1-cdon
Condition:	chemical treatment: Cyclopamine
Knockdown Reagent:	MO1-cdon
Anatomical Terms:	midbrain hindbrain boundary optic stalk
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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