FIGURE

Fig. 2

ID

ZDB-FIG-140506-4

Publication

Shive et al., 2014 - BRCA2 and TP53 collaborate in tumorigenesis in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Malignant zebrafish tumors frequently develop LOH for brca2 and/or tp53.

(A–C), Before (upper panels) and after (lower panels) images of LCM-guided sample collection from an MPNST (A), an MPNST and a nephroblastoma (B), and a normal liver (C). Regions of sample collection are outlined in color. (D) MPNST from a brca2+/m;tp53+/m zebrafish shows loss of the brca2 and tp53 wildtype alleles. (E) MPNST and nephroblastoma from a brca2+/m;tp53+/m zebrafish show disparate LOH profiles. LOH, loss of heterozygosity; MPNST, malignant peripheral nerve sheath tumor; NB, nephroblastoma.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	brca2^hg5/+; tp53^zdf1/+
Observed In:	peripheral neuron myelin sheath whole organism whole organism nephroblastoma
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One