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Fig. 2
Malignant zebrafish tumors frequently develop LOH for brca2 and/or tp53.
(A–C), Before (upper panels) and after (lower panels) images of LCM-guided sample collection from an MPNST (A), an MPNST and a nephroblastoma (B), and a normal liver (C). Regions of sample collection are outlined in color. (D) MPNST from a brca2+/m;tp53+/m zebrafish shows loss of the brca2 and tp53 wildtype alleles. (E) MPNST and nephroblastoma from a brca2+/m;tp53+/m zebrafish show disparate LOH profiles. LOH, loss of heterozygosity; MPNST, malignant peripheral nerve sheath tumor; NB, nephroblastoma.
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