FIGURE

Fig. 7

ID

ZDB-FIG-130726-41

Publication

Melvin et al., 2013 - A morpholino-based screen to identify novel genes involved in craniofacial morphogenesis

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Fig. 7

Absence of p53 alleviates the cartilage phenotypes present in wu:fb16h09 and pkdcc morphants. A: Flat-mounted neurocranium of wu:fb16h09 morphant in wildtype zebrafish after injection of 10 ng ATG Morpholino. B: Flat-mounted neurocranium of wu:fb16h09 morphant in p53 null zebrafish after injection of 10 ng ATG Morpholino. (Note that the wu:fb16h09 ATG Morpholino only generates neurocranial defects and so we were not able to assess the influence of p53 on viscerocranial defects in this experiment.) C: Flat-mounted cranial cartilages of pkdcc morphant in wildtype zebrafish after injection of 20 ng ATG Morpholino. D: Flat-mounted cranial cartilages of pkdcc morphant in p53 null zebrafish after injection of 20 ng ATG Morpholino. Abbreviations as in Figure 1.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1 + MO1-ndnf (AB) tp53^zdf1/zdf1 + MO1-pkdccb (AB)
Knockdown Reagents:	MO1-ndnf MO1-pkdccb
Observed In:	chondrocranium
Stage:	Day 5

Phenotype Detail

Acknowledgments

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