FIGURE

Fig. 4

ID

ZDB-FIG-121116-45

Publication

Tessadori et al., 2012 - Identification and functional characterization of cardiac pacemaker cells in zebrafish

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Fig. 4

Isl1 cells have pacemaker activity.

(A–C) Optical mapping on an explanted, contracting adult zebrafish tg(isl1BAC:GalFF; UAS:GFP) heart. Arrow indicates the sinus venosus in all panels. (A) Explanted adult zebrafish heart. (B) GFP-fluorescent cells reporting Isl1 expression are situated at the sinus venosus. (C) The activation pattern measured by di-4-ANEPPS fluorescence shows that the GFP+ myocytes are situated in the area of earliest activation. (D) Typical action potentials of freshly isolated GFP⁺ and GFP^- myocytes. The GFP^- cell was stimulated at 3 Hz. The inset displays a representative example of a GFP+ myocyte.

Expression Data

Gene:	EGFP
Fish:	hu6635Tg; nkuasgfp1aTg
Anatomical Term:	sinus venosus
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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