ZFIN Image: Tessadori et al., 2012, Fig. 4

Image

Figure Caption

Fig. 4 Isl1 cells have pacemaker activity.

(A–C) Optical mapping on an explanted, contracting adult zebrafish tg(isl1BAC:GalFF; UAS:GFP) heart. Arrow indicates the sinus venosus in all panels. (A) Explanted adult zebrafish heart. (B) GFP-fluorescent cells reporting Isl1 expression are situated at the sinus venosus. (C) The activation pattern measured by di-4-ANEPPS fluorescence shows that the GFP+ myocytes are situated in the area of earliest activation. (D) Typical action potentials of freshly isolated GFP⁺ and GFP^- myocytes. The GFP^- cell was stimulated at 3 Hz. The inset displays a representative example of a GFP+ myocyte.

Figure Data

Expression / Labeling details

Acknowledgments

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