FIGURE

Fig. 1

ID

ZDB-FIG-110531-1

Publication

Mapp et al., 2011 - Zebrafish Prickle1b mediates facial branchiomotor neuron migration via a farnesylation-dependent nuclear activity

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Fig. 1

prickle1b is disrupted in zebrafish fh122 mutants. (A) The domain structure of Pk1b. NLS, nuclear localization signal. (B,C) Lateral brightfield views of 48 hpf wild-type (WT) (A) and pk1b^fh122/fh122 (B) embryos. pk1b^fh122/fh122 embryos are morphologically normal. Anterior is to the left. (D,E) Maximum projection dorsal views of cranial branchiomotor neurons (CBMNs) in 48 hpf Tg(islet1:GFP) embryos. Rhombomeres are indicated (r2-r6). In WT embryos (C), facial branchiomotor neuron (FBMN) cell bodies migrate from r4 to r6. In fh122 mutants (D), FBMNs fail to undergo caudal tangential migration and cell bodies cluster in r4. (F) Amino acid sequence of Pk1b in WT and pk1b^fh122/fh122 fish. The fh122 mutation results in a C-to-F transition in the Pk1b farnesylation (CaaX) motif. Scale bars: 500 μm in B; 50 μm in D.

Expression Data

Gene:	GFP
Fish:	rw0Tg prickle1b^fh122/fh122; rw0Tg
Anatomical Term:	facial nerve motor nucleus
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	prickle1b^fh122/fh122; rw0Tg
Observed In:	facial nerve motor nucleus neuron migration
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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