FIGURE

Fig. 6

ID

ZDB-FIG-110322-48

Publication

Veth et al., 2011 - Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

Other Figures

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Fig. 6

Retinal proliferation and apoptosis.

A–F Mcm5 expression in 1 (A–C) and 2-month (D–F) cryosections. Dashed white lines denote proliferative ciliary marginal zone (CMZ) of the retina; asterisks indicate autofluorescent blood vessels. G Quantitation of apoptotic cells identified on whole retina flat-mounts by activated caspase-3 (aCasp3) immunofluorescence. H Confocal images of aCasp3-positive cell in 1 year old bugeye mutant. Upper shows compressed z-stacks, lower shows 90°rotation to reveal z location of positive cell (arrow). The flat mounted retinas were orientated with retinal ganglion cell layer up. n = 15 eyes for each condition; ***p<0.001, **p<0.01, n.s., not significant (t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1
Observed In:	ciliary marginal zone neuronal stem cell retina stem cell population maintenance
Stage Range:	Days 45-89 to Adult

Phenotype Detail

Acknowledgments

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