FIGURE

Fig. 3

ID

ZDB-FIG-110322-46

Publication

Veth et al., 2011 - Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

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Fig. 3

Eye growth and relative refractive errors in bugeye/lrp2 mutants.

A bugeye mutants have a greater eye area to body length ratio (E:B) than age-matched wild-types beginning at 2 months (p<0.05, t-test), which becomes more pronounced with age. Each dot represents the E:B for an individual eye. B Histological transverse sections through the whole eye show an increased depth of the vitreous chamber (from the lens to retina) in bugeye (right) as compared to wild-type fish (left). C Diagram showing the calculation of relative refractive error (RRE): lens radius (l) and retina radius (r), using a focal length of the lens (f) as 2.32 x lens radius. D The RRE measurements revealed mild but significant myopia in 1-month bugeye fish (p = 0.0002, t-test), that becomes more dramatic at 2 months of age (p<0.0001, t-test). n = 6 eyes each for 1 month TL and bugeye; n = 16 and 22 eyes for 2 month TL wild-type and bugeye, respectively.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1
Observed In:	eye posterior segment eye whole organism
Stage Range:	Days 30-44 to Adult

Phenotype Detail

Acknowledgments

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