FIGURE

Fig. 1

ID

ZDB-FIG-110322-45

Publication

Veth et al., 2011 - Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma

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Fig. 1

Adult bugeye zebrafish have enlarged eye globes, thinned retinas, and elevated intraocular pressure without iridocorneal angle obstruction or malformation.

A,C Dorsal views of adult wild-type (A) and bugeye (C) zebrafish. B,D Histology of central retina sections at 6 months in wild-type (B) and mutant (D) eyes. E-H Histology of wild-type (E,F) and bugeye mutant (G,H) iridocorneal angles in the dorsal region (E,G) or at the ventral canalicular aqueous humor drainage region (F,H). I Intraocular pressures (IOP) in adult wild-type and bugeye zebrafish. IOPs in bugeye fish were elevated compared to age and size matched fish from TL wild-type stain (p<0.0001, t-test). Scale bars: A,C = 4 mm; B,D = 50 μm; E-H = 40 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1
Observed In:	anterior segment eye aqueous humor ciliary zone eye retinal neural layer
Stage:	Adult

Phenotype Detail

Acknowledgments

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