FIGURE

Fig. S4

ID

ZDB-FIG-101119-26

Publication

Cao et al., 2009 - Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

Other Figures

All Figure Page

Back to All Figure Page

Fig. S4

Comparison of phenotypes caused by hdac1 depletion and VPA and TSA treatment. (A) Stunted pectoral fin (blue arrow) development on 3 dpf in a hdac1/hi1618 mutant embryo (1618), a wild-type embryo treated with 300 nM TSA (TSA), 20 μM VPA (VPA), and 50 μm (VPM) from the 30% epiboly stage. (B) Pericardiac edema (red arrow) on 3 dpf in a hdac1/hi1618 mutant embryo. WT: wild-type sibling. mut: hdac1/hi1618 mutant. (C) Treatment of 300 nM TSA from the 30% epiboly stage leads to pericardiac edema (red arrow) on 3 dpf, while similar treatment with 50 μM VPM does not. (D) Treatment of 20 μM TSA from the 30% epiboly stage leads to pericardiac edema (red arrow) on 3 dpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA