FIGURE

Fig. S1

ID

ZDB-FIG-101105-1

Publication

Vermot et al., 2009 - Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart

Other Figures

All Figure Page

Back to All Figure Page

Fig. S1

Oscillatory flow is observed in the AV canal before valves become functional. (A-D) Confocal scans of hearts (ventral view, anterior to the top) at four developmental stages showing the morphology of the developing heart between 36 and 120 hpf. The endocardial tissue in the AV canal at 48 hpf in shown by the arrow in (C). Valve leaflets appear at 84 hpf and are mature by 120 hpf. The black box underlines the location of blood flow analysis for each stage (A-D). Scale bar indicates 50 μm. (E-H) Transvalvular flow direction over time shows that mature valve leaflets are necessary to prevent retrograde flow in the heart. Anterograde flow from the atrium to ventricle is shown in black, retrograde flow from the ventricle to the atrium in red, and no flow between the chambers is shown in white.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.