FIGURE

Fig. 7

ID

ZDB-FIG-100903-47

Publication

Wang et al., 2010 - Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis

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Fig. 7

Knockdown of Moesin1 results in extensive loss of adherens junctions without affecting ZO-1-associated junctions. (A-F) Confocal images of ISVs in the Tg(fli1:egfp)^y1 zebrafish embryos that were probed for ZO-1 (red) at 54 hpf. (A-C) ZO-1-associated junctions are seen in a control embryo. (D-F) The ZO-1-associated junctions (arrow) are observed in Moesin1 knockdown embryos but are not well separated from one another. (G-L) Confocal images of ISVs in Tg(fli1:egfp)^y1 embryos labeled with Ve-cadherin (red) at 54 hpf. (G-I) Ve-cadherin labeling in a control embryo. (J-L) Moesin1 knockdown causes an extensive loss of Ve-cadherin labeling (arrowheads); some weak Ve-cadherin signals are observed (arrows).

Expression Data

Genes:	cdh5 EGFP
Antibodies:	Ab1-cdh5 Ab1-tjp1
Fish:	y1Tg y1Tg + MO1-msna
Knockdown Reagent:	MO1-msna
Anatomical Terms:	blood vessel endothelial cell adherens junction blood vessel endothelial cell bicellular tight junction intersegmental vessel blood vessel endothelial cell
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	y1Tg + MO1-msna
Knockdown Reagent:	MO1-msna
Observed In:	adherens junction organization blood vessel endothelial cell adherens junction
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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