FIGURE

Fig. S4

ID

ZDB-FIG-100504-67

Publication

Mao et al., 2009 - Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb

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Fig. S4

Shh Expression in the Zebrafish Pectoral Fin Is Dependent on a FGF Receptorlike Activity
Embryos were cultured from 12 hours post-fertilization in the presence of 30μM SU5402 dissolved in DMSO. Control embryos were cultured in the presence of DMSO alone. A complete abolition of erm, pea3 and etv5 expression was observed in SU5402-treated fin buds 12 hours after treatment commenced while Shh was robustly expressed in control embryos (fin buds marked with arrow), suggesting their transcription depends on Fgf signaling.

Expression Data

Genes:	etv4 etv5a etv5b
Fish:	WT
Condition:	chemical treatment: SU5402
Anatomical Term:	pectoral fin bud
Stage:	Prim-5

Expression Detail

Gene	Fish	Conditions	Stage	Qualifier	Anatomy	Assay
etv4	WT	control	Prim-5		pectoral fin bud	ISH
etv4	WT	chemical treatment: SU5402	Prim-5	Not Detected	pectoral fin bud	ISH
etv5a	WT	control	Prim-5		pectoral fin bud	ISH
etv5a	WT	chemical treatment: SU5402	Prim-5	Not Detected	pectoral fin bud	ISH
etv5b	WT	control	Prim-5		pectoral fin bud	ISH
etv5b	WT	chemical treatment: SU5402	Prim-5	Not Detected	pectoral fin bud	ISH

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Acknowledgments

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Reprinted from Developmental Cell, 16(4), Mao, J., McGlinn, E., Huang, P., Tabin, C.J., and McMahon, A.P., Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb, 600-606, Copyright (2009) with permission from Elsevier. Full text @ Dev. Cell