FIGURE

Fig. 3

ID
ZDB-FIG-091014-3
Publication
Kinkel et al., 2009 - Cyp26 enzymes function in endoderm to regulate pancreatic field size
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Fig. 3

Cyp26 enzymes set the anterior limit of the insulin domain. (A) Wild-type insulin domain. (B) insulin is expanded in Cyp26a1-deficient gir mutants. (C–E) Knockdown of Cyp26b1 and Cyp26c1 singly or in combination does not expand insulin. (F and G) Knockdown of Cyp26b1 or Cyp26c1 in gir mutants expands the pancreas as with gir alone. (H) Deficiency in all 3 Cyp26 enzymes expands the pancreas more than with Cyp26a1 deficiency alone. All panels show 24 hpf, dorsal view, anterior to the left, 200x magnification. (I) Size of the insulin domain in response to Cyp26 deficiency. Note that the Cyp26a1 morpholino does not expand the pancreas as dramatically as in gir mutants. Wild-type, n = 19; a1MO, n = 10; b1MO, n = 34; c1MO, n = 28; b1 + c1 MO, n = 20; R115866, n = 10; gir + b1MO, n = 17; gir + c1MO, n = 11; gir + b1 + c1MO, n = 11.

Expression Data
Gene:
Fish:
Knockdown Reagents:
Anatomical Term:
Stage: Prim-5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagents:
Observed In:
Stage: Prim-5

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA
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