FIGURE

Fig. 5

ID

ZDB-FIG-081205-22

Publication

Snelson et al., 2008 - Formation of the asymmetric pineal complex in zebrafish requires two independently acting transcription factors

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Fig. 5

Double homozygous flh;fby mutants exhibit an additive phenotype. All panels are dorsal views of the epithalamus of 4 d larvae. A: In fby single mutants or (B) flh;fby double mutants, only a few disorganized parapineal cells are specified, and they fail to migrate to the left side of the brain. C: fby single mutants form a pineal organ. D: flh;fby double mutant larvae have both a reduced pineal, similar to flh single mutants (compare to Fig. 3D). E: In fby single mutants and (F) flh;fby double mutants, reduced lov expression is detected in the left habenula. Scale bars = 25 μm. G: Summary of tbx2b and flh activity in pineal complex development. The activity of tbx2b gives parapineal precursors their identity, while flh is needed for proliferation of pineal precursor cells. Expression of tbx2b does not require flh activity.

Expression Data

Genes:	gfi1ab GFP kctd12.1
Antibodies:	Ab3-GFP zpr-1
Fish:	tbx2b^c144/c144 tbx2b^c144/c144; zf104Tg tbx2b^c144/c144; noto^n1/n1 tbx2b^c144/c144; noto^n1/n1; zf104Tg
Anatomical Terms:	epiphysis habenula parapineal organ pineal complex
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tbx2b^c144/c144 tbx2b^c144/c144; noto^n1/n1; zf104Tg
Observed In:	epiphysis epithalamus development parapineal organ cell pineal gland development
Stage:	Day 4

Phenotype Detail

Acknowledgments

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