FIGURE

Fig. 1

ID

ZDB-FIG-080401-12

Publication

Ignatius et al., 2008 - colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis

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Fig. 1

Melanophore development is defective in hdac1^col mutants. Lateral views of live embryos at 27 hpf (A, B) and 3 dpf (C, D). (A, B) At 27 hpf in wild-type embryos melanophores are present posterior to the eye and otic vesicle and are migrating over the flank of the embryo. In hdac1^col mutants, there are fewer melanophores and most of the melanophores are located posterior to the otic vesicle (arrowhead). There are no migrating melanophores in hdac1^col mutants. (C, D) By 3 dpf, melanophores are present in four stripes in wild-type: dorsal (d), lateral (l), ventral (v) and yolk (y). In hdac1^col mutants melanophore numbers do not recover. Melanophores present in hdac1^col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otic vesicle (arrows, arrowhead). Melanophores that do migrate ventrally in hdac1col fail to migrate and are mainly localized to the dorsal stripe and a patch of melanophores posterior to the otp>col mutants are present in the anterior ventral stripe over the yolk extension. Xanthophores, which give a yellowish hue to embryos, are present in the head and over the flank of wild-type embryos and hdac1^col mutants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hdac1^b382/b382
Observed In:	melanocyte melanophore stripe melanophore stripe melanocyte pigmentation yolk melanophore stripe
Stage Range:	Prim-5 to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 313(2), Ignatius, M.S., Moose, H.E., El-Hodiri, H.M., and Henion, P.D., colgate/hdac1 repression of foxd3 expression is required to permit mitfa-dependent melanogenesis, 568-583, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.