FIGURE

Fig. 2

ID

ZDB-FIG-080325-7

Publication

Sperber et al., 2008 - Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements

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Fig. 2

dlx1a and dlx2a are required for proper head outgrowth and arch cartilage patterning. (A–D) Lateral views of head morphology in 5-day-old larvae that received the (A) control MO, 0.5 mM; (B) dlx1aMO, 0.5 mM; (C) dlx2aMO, 0.25 mM; (D) an equal combination of dlx1aMO + dlx2aMO 0.25 mM each. (E–P) Cartilage elements stained with alcian blue. (E–H) are lateral views; (I–L) are ventral view. The inset in panel H is a lateral oblique view showing loss of the interhyal by fusion of hyosymplectic and ceratohyal elements (arrowhead). (M–P) Dissected ceratobranchial arch elements, numbered. cb, ceratobranchials; ch, ceratohyal; eth, ethmoid plate; hys, hyosymplectic; ih, interhyal; M, Meckel′s cartilage; pq, palatoquadrate. Arrows (A–D) indicate position of the mouth; asterisk in panel P indicates site of lateral branching. (A–P) Anterior is to the left. Scale bar in panel A: 250 µm; panels E and I: 100 μm; panel H inset, and M: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dlx1a WT + MO2-dlx2a WT + MO1-dlx1a + MO2-dlx2a
Knockdown Reagents:	MO1-dlx1a MO2-dlx2a
Observed In:	ceratobranchial cartilage ceratobranchial cartilage chondrocyte ceratohyal cartilage ethmoid cartilage head hyosymplectic cartilage interhyal cartilage Meckel's cartilage palatoquadrate cartilage pharyngeal arch cartilage pharyngeal arch cartilage chondrocyte trabecula cranii
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 314(1), Sperber, S.M., Saxena, V., Hatch, G., and Ekker, M., Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements, 59-70, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.