FIGURE

Fig. 8

ID

ZDB-FIG-070718-22

Publication

Miyasaka et al., 2007 - Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system

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Fig. 8

Projection of pioneer axons is impaired in zebrafish ody mutant embryos. ody/ody;omp:yfp/+ (A-I) and omp:yfp/+ (J-L) embryos double labeled with zns-2 antibody (A,D,G,J; magenta in C,F,I,L) and anti-GFP antibody (B,E,H,K; green in C,F,I,L) at 1.5 dpf are shown in frontal views as z-stacked images. Projection patterns of pioneer axons in ody mutants vary, ranging from no axon reaching the presumptive OB (A-C) to an essentially normal projection (G-I). Note that projection defects with intermediate severity are observed (D-F). Arrowheads indicate accumulated zns-2-positive axons near the placode-telencephalon border. Scale bar: 50 µm. d, dorsal; l, lateral; op, olfactory placode; tel, telencephalon. The asterisk in E marks mispositioned olfactory neurons.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cxcr4b^{t26035/t26035}
Observed In:	axon extension involved in axon guidance olfactory receptor cell olfactory receptor cell axon
Stage:	Prim-25

Phenotype Detail

Acknowledgments

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