FIGURE

Fig. 7

ID

ZDB-FIG-070718-21

Publication

Miyasaka et al., 2007 - Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system

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Fig. 7

Zebrafish ody mutant embryos show OSN axon projection defects. (A-D) Axon trajectories from both ciliated and microvillous OSNs are labeled at 3 dpf by whole-mount immunohistochemistry with anti-PCAM antibody, and are shown in frontal views as z-stacked images. ody/ody embryos are classified into three groups according to the severity of axon pathfinding defects (B-D): class 1 (8 of 18 embryos), a virtually wild-type projection pattern; class 2 (5 of 18), unilatetal projection defects; class 3 (5 of 18), bilateral projection defects. Projection patterns of all ody/+ embryos (n=15) fall into class 1. Asterisks in A indicate neuromasts in the lateral line system. Scale bar: 100 µm. d, dorsal; ob, olfactory bulb; oe, olfactory epithelium; v, ventral.

Expression Data

Gene:	ncam1b
Fish:	cxcr4b^{t26035/t26035} cxcr4b^t26035/+
Anatomical Terms:	ciliated olfactory receptor neuron microvillous olfactory receptor neuron
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cxcr4b^{t26035/t26035}
Observed In:	axon extension involved in axon guidance olfactory receptor cell axon
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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