FIGURE

Fig. 2

ID

ZDB-FIG-070718-17

Publication

Miyasaka et al., 2007 - Cxcl12/Cxcr4 chemokine signaling is required for placode assembly and sensory axon pathfinding in the zebrafish olfactory system

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Fig. 2

Assembly of cxcr4b-expressing cells into the olfactory placode is perturbed in ody/ody embryos. Zebrafish ody/ody and ody/+ embryos were hybridized with cRNA probe against cxcr4b. (A,B,F,G) Dorsal views with anterior to the bottom. (C,D,H,I) Frontodorsal views with anteroventral to the bottom. (E,J) Frontal views with ventral to the bottom. At 12 and 14 hpf, the arrangement of cxcr4b-expressing cells in ody/ody embryos (F,G) is indistinguishable from that in ody/+ embryos (A,B). At 16 hpf, cxcr4b-expressing cells in ody/ody embryos disperse laterally (arrows in H) and anteroventrally (bracket in H) away from the lateral edge of developing neural tube. At 18 hpf, substantial numbers of cxcr4b-expressing cells are mispositioned ventrally (brackets in I). By 20 hpf, some cxcr4b-expressing cells (brackets in J) fail to join a cluster positioned at the correct site of the olfactory placode. Scale bar: 50 µm

Expression Data

Gene:	cxcr4b
Fish:	cxcr4b^{t26035/t26035} cxcr4b^t26035/+
Anatomical Terms:	neurogenic placode olfactory placode
Stage Range:	5-9 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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