FIGURE

Fig. 6

ID

ZDB-FIG-060203-21

Publication

Cunliffe et al., 2006 - Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS

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Fig. 6

Defective down-regulation of sox2 expression in the developing hdac1 mutant CNS. Transverse sections through rhombomere 5 in the hindbrain showing that sox2 expression is restricted to the ventricular zone in wild-type embryos at (A) 28 hpf, (C) 39 hpf, (E) 50 hpf. In hdac1 mutants, expression of sox2 encompasses both the ventricular zone and ventro-lateral (arrows) hindbrain territories at 28 hpf (B). At 39 hpf (D) the sox2 expression domain is thickened in the hdac1 mutant hindbrain and the size of the sox2-negative ventro-lateral domain is much reduced. At 50 hpf, sox2 expression remains strong in the dorsal ventricular zone of the hdac1 mutant hindbrain (F), and there is a persistent major deficit of sox2-negative cells ventrally.

Expression Data

Gene:	sox2
Fish:	WT hdac1^hi1618Tg
Anatomical Terms:	hindbrain otic vesicle
Stage Range:	Prim-5 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 123(1), Cunliffe, V.T., and Casaccia-Bonnefil, P., Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS, 24-30, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.