Genomic Feature
zdf10
- ID
- ZDB-ALT-060519-4
- Name
- zdf10
- Synonyms
-
- sym1 (1)
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- ENU
- Lab of Origin
- A. Thomas Look Lab
- Current Source
-
European Zebrafish Resource Center (EZRC)
(
order this
)
Zebrafish International Resource Center (ZIRC) ( order this ) - Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 6: 32093063 (GRCz11) (1) Details
- Nucleotide change
- C/-
- Variant Notes
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 1 bp deleted at position 537 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
CTGAGGATGGGCGCGATGGCAGCTGATGTCCGGGTTAAGGACAGGGACTGAGCGCTCAGTAAGGCGGACTGCACCGTCACGGGTGGCCGCAGGAAAGTCTGTGCGCTCGTAGAGCTGCTGGAGACCCCGATGATGTTTTCTATGCTGAATGATGGTCGACTGGACGGCTCGGATTTGATAATCGACGCGGTGCTCAGGCTATTTAGCTGTAACTGGAGACTTGGACTTAGCTGAGAGCTGAAAGCTTTTCTGTTCAGTTCGGCGGAGGGTAAGAGAGGCACCGCCGGAGGGAGCATCGGACCCACAGGGGGAATGTACGGGTACTGCAGAGCGGCAGGGTGCGTGTATGCAGCCGGGTGAATTCCATAATGACGTCCATATGGATTCCCAATGCCGTATGCCCCAAAACTCTGCATCATGAGGGCGGTCTGGTCCCTGAGAATGTCCGGCTGATGCCTCTTGAAGCGTTTTCTCCTCCTCAGAAAGCTACCGTTGTCGAA
C/- ATATCTTCCGACTGGGGGTCGAGGGTCCAGTAGTTGCCTTTGCCCGGGTTGCCCGGTTCCCGTGGGATCTTGACGAAGCAGTCGTTGAGCGACAAGTTATGGCGAATGGAGTTTTGCCAGGCCGGAAACTTCTCCCGGTAGTATGGGAAGCGGTTGCTGATGAACTCGCAGATTCCACTGAGCGTCAACTTCTTCTGCGGGCTCTGGAGGATGGCCATGGTGATGAGGGCGATGTACGAGTAGGGCGGCTTTACCAGGCTGCTCTTGGGCTTGTTTTGCATGGGACCGGTGGAGCTCTCCTGAGCATCCCCCTTGGTCTCTCCGTCAGCGTTGCTCTCGCAGGGACTGTCGCTGCGCTCCTTCACCTCGATCTCCTCCACCTCATCTCCCCGGTCCTGCATGCACTGGCTTTCGCAGTCACTGTCCTGCTCCATCCCCTCGTCACCCTCCCCGACCACGTCGATATCCACATCGTCAGCTGTGAGCACGGTCTGACCGGA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| foxd3zdf10/zdf10 | Homozygous | Unknown | 2 figures  from 2 publications | 12 figures from Stewart et al., 2006 | |
| foxd3zdf10/zdf10 | Homozygous | ♀+/- ♂+/- | 2 figures from 2 publications | 5 figures from 3 publications | |
| foxd3zdf10/zdf10 (AB) | Homozygous | ♀+/- ♂+/- | Fig. 3 from Curran et al., 2010 | Fig. 2 from Curran et al., 2010 | |
| foxd3zdf10/+ (AB) | Heterozygous | Unknown | |||
| foxd3zdf10/+ (WIK/AB) | Heterozygous | Unknown | |||
| foxd3zdf10 | Unknown | Unknown | |||
| foxd3zdf10 (AB) | Unknown | Unknown | Fig. 2 from Curran et al., 2009 | ||
| foxd3zdf10/+; foxd3m188/+ | Complex | Fig. S2 from Montero-Balaguer et al., 2006 | |||
| foxd3zdf10/zdf10; jh17Tg; sl2Tg | Complex | 3 figures from Pope et al., 2014 | Fig. 8 from Pope et al., 2014 | ||
| foxd3zdf10/zdf10; rw0Tg | Complex | Fig. 11 from Cox et al., 2011 |
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Supplemental Information
- Genotyping protocol
- zdf10.pdf
- Faucz, F.R., Horvath, A.D., Assié, G., Almeida, M.Q., Szarek, E., Boikos, S., Angelousi, A., Levy, I., Maria, A.G., Chitnis, A., Antonescu, C., Claus, R., Bertherat, J., Plass, C., Eng, C., Stratakis, C.A. (2023) Embryonic stem cell factor FOXD3 (Genesis) defects in gastrointestinal stromal tumors. Endocrine-related cancer. 30(10):
- Vöcking, O., Van Der Meulen, K., Patel, M.K., Famulski, J.K. (2022) Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10. Differentiation; research in biological diversity. 130:324232-42
- Monnot, P., Gangatharan, G., Baraban, M., Pottin, K., Cabrera, M., Bonnet, I., Breau, M.A. (2021) Intertissue mechanical interactions shape the olfactory circuit in zebrafish. EMBO reports. 23(2):e52963
- Petratou, K., Spencer, S.A., Kelsh, R.N., Lister, J.A. (2021) The MITF paralog tfec is required in neural crest development for fate specification of the iridophore lineage from a multipotent pigment cell progenitor. PLoS One. 16:e0244794
- Bryan, C.D., Casey, M.A., Pfeiffer, R.L., Jones, B.W., Kwan, K.M. (2020) Optic cup morphogenesis requires neural crest-mediated basement membrane assembly. Development (Cambridge, England). 147(4):
- Cox, J.A., Zhang, B., Pope, H.M., Voigt, M.M. (2016) Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS One. 11:e0148726
- Pope, H.M., Voigt, M.M. (2014) Peripheral glia have a pivotal role in the initial response to axon degeneration of peripheral sensory neurons in zebrafish. PLoS One. 9:e103283
- Powell, D.R., Hernandez-Lagunas, L., Lamonica, K., and Artinger, K.B. (2013) Prdm1a directly activates foxd3 and tfap2a during zebrafish neural crest specification. Development (Cambridge, England). 140(16):3445-3455
- Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M. (2011) Diverse mechanisms for assembly of branchiomeric nerves. Developmental Biology. 357(2):305-17
- Culbertson, M.D., Lewis, Z.R., and Nechiporuk, A.V. (2011) Chondrogenic and Gliogenic Subpopulations of Neural Crest Play Distinct Roles during the Assembly of Epibranchial Ganglia. PLoS One. 6(9):e24443
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