FIGURE

Fig. 3

ID

ZDB-FIG-100806-4

Publication

Curran et al., 2010 - Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest

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Fig. 3

foxd3/mitfa double mutant exhibits partial rescue of iridophores. (A–D) Incident light reveals iridophores on trunk and tail of 51–54 hpf zebrafish, lateral view, anterior left, 5x. (A) Wild-type zebrafish displays normal numbers of iridophores. (B) mitfa-/- (nacre) displays supernumerary iridophores. (C) foxd3-/- (sym1) displays iridophore reduction. (D) foxd3/mitfa double mutant exhibits partial rescue of iridophore phenotype as compared to foxd3-/- reduction alone. (E) Iridophores were counted along the dorsal and ventral stripes from the posterior tail region, between the cloacae and tail tip. Cell counts taken from 51 zebrafish for each genetic background: Total cell counts (wild-type: 1144), (foxd3-/-: 305), (mitfa-/-: 1615), (foxd3/mitfa double mutant: 748). Mean iridophore cell counts: (wild-type: 22.9), (foxd3-/-: 6.1), (mitfa-/-: 32.3), (foxd3/mitfa double mutant: 15.0). Bars = s.d. Scale bar: (A–D) 100 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxd3^zdf10/zdf10 (AB) mitfa^w2/w2 (AB) mitfa^w2/w2; foxd3^zdf10/zdf10
Observed In:	iridophore
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 344(1), Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W., Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest, 107-118, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.