ZFIN All Figures, Mathews <i>et al.</i>, 2014

Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP sox10
Antibodies:	Ab-3A10 Ab1-sox10
Fish:	vu12Tg hmgcs1^vu57/vu57; vu12Tg
Anatomical Terms:	dorsal longitudinal fasciculus medial longitudinal fasciculus spinal cord oligodendrocyte spinal cord ventral region
Stage Range:	Protruding-mouth to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	hmgcs1^vu57/vu57 (AB) hmgcs1^vu57/vu57; vu12Tg
Observed In:	brain dorsal longitudinal fasciculus heart mandibular arch skeleton medial longitudinal fasciculus oligodendrocyte spinal cord spinal cord oligodendrocyte ventral spinal nerve
Stage Range:	Protruding-mouth to Day 4

Phenotype details

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	dhrs12la mag mbpa mpz plp1a
Fish:	WT hmgcs1^vu57/vu57 (AB)
Anatomical Terms:	hindbrain oligodendrocyte spinal cord oligodendrocyte whole organism
Stage Range:	Protruding-mouth to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	hmgcs1^vu57/vu57 (AB)
Observed In:	central nervous system myelination hindbrain oligodendrocyte oligodendrocyte differentiation spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 4

Phenotype details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP mbpa plp1a
Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg hmgcs1^vu57/vu57; vu12Tg
Condition:	chemical treatment: atorvastatin
Anatomical Terms:	hindbrain oligodendrocyte spinal cord oligodendrocyte spinal cord ventral region whole organism
Stage Range:	Protruding-mouth to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg hmgcs1^vu57/vu57; vu12Tg
Condition:	chemical treatment: atorvastatin
Observed In:	dorsal longitudinal fasciculus hindbrain oligodendrocyte oligodendrocyte oligodendrocyte development oligodendrocyte differentiation spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 4

Phenotype details

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP mbpa plp1a
Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg vu16Tg hmgcs1^vu57/vu57; vu12Tg hmgcs1^vu57/vu57; vu16Tg
Conditions:	chemical treatment: drug chemical treatment: GGTI-2133 chemical treatment: lonafarnib
Anatomical Terms:	hindbrain oligodendrocyte oligodendrocyte cytoplasm oligodendrocyte plasma membrane spinal cord oligodendrocyte spinal cord ventral region
Stage Range:	Protruding-mouth to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg vu16Tg hmgcs1^vu57/vu57; vu12Tg hmgcs1^vu57/vu57; vu16Tg
Conditions:	chemical treatment: drug chemical treatment: GGTI-2133 chemical treatment: lonafarnib
Observed In:	dorsal longitudinal fasciculus hindbrain oligodendrocyte oligodendrocyte development oligodendrocyte differentiation protein farnesylation protein geranylgeranylation spinal cord central nervous system myelination spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 4

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP mbpa plp1a
Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg hmgcs1^vu57/vu57; vu12Tg
Conditions:	chemical treatment: cholesterol chemical treatment: Ro 48-8071
Anatomical Terms:	hindbrain oligodendrocyte spinal cord oligodendrocyte spinal cord ventral region
Stage Range:	Protruding-mouth to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT hmgcs1^vu57/vu57 (AB) vu12Tg hmgcs1^vu57/vu57; vu12Tg
Conditions:	chemical treatment: cholesterol chemical treatment: Ro 48-8071
Observed In:	cholesterol biosynthetic process dorsal longitudinal fasciculus hindbrain oligodendrocyte oligodendrocyte development oligodendrocyte differentiation spinal cord oligodendrocyte
Stage Range:	Protruding-mouth to Day 4

Phenotype details

Fig. 8

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Gene:	EGFP
Antibody:	Ab1-tuba
Fish:	vu16Tg co18Tg; co19Tg hmgcs1^vu57/vu57; vu16Tg
Conditions:	chemical treatment: cholesterol chemical treatment: Ro 48-8071
Anatomical Terms:	dorsal longitudinal fasciculus axon dorsal longitudinal fasciculus myelin sheath spinal cord oligodendrocyte
Stage:	Protruding-mouth

Expression / Labeling details

PHENOTYPE:

Fish:	vu16Tg co18Tg; co19Tg hmgcs1^vu57/vu57; vu16Tg
Conditions:	chemical treatment: cholesterol chemical treatment: Ro 48-8071
Observed In:	dorsal longitudinal fasciculus axon ensheathment in central nervous system
Stage:	Protruding-mouth

Phenotype details

Acknowledgments

Full text @ J. Neurosci.

Mathews et al., 2014

ZDB-PUB-140513-462
PMID:24573296

Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression

Mathews et al., 2014 ZDB-PUB-140513-462 PMID:24573296

Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression

Mathews et al., 2014

ZDB-PUB-140513-462
PMID:24573296