Gene
plp1a
- ID
- ZDB-GENE-001202-1
- Name
- proteolipid protein 1a
- Symbol
- plp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be a structural constituent of myelin sheath. Acts upstream of or within myelination. Predicted to be located in membrane. Predicted to be active in myelin sheath and plasma membrane. Is expressed in central nervous system; glial cell; and neural tube. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 26 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 2 | Alliance | Spastic paraplegia 2, X-linked | 312920 |
| Pelizaeus-Merzbacher disease | Alliance | Pelizaeus-Merzbacher disease | 312080 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Myelin proteolipid protein PLP | Myelin proteolipid protein PLP, conserved site |
|---|---|---|---|
|
UniProtKB:Q8UUT6
|
245 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27I16 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-169H1 | ZFIN Curated Data | |
| Encodes | EST | fc27f01 | ZFIN Curated Data | |
| Encodes | EST | fj42d08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110499 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192273 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_175576 (1) | 4574 nt | ||
| Genomic | GenBank:CR753843 (1) | 112358 nt | ||
| Polypeptide | UniProtKB:Q8UUT6 (1) | 245 aa |
- Kuil, L.E., Kakiailatu, N.J.M., Windster, J.D., Bindels, E., Zink, J.T.M., van der Zee, G., Hofstra, R.M.W., Shepherd, I.T., Melotte, V., Alves, M.M. (2023) Unbiased characterization of the larval zebrafish enteric nervous system at a single cell transcriptomic level. iScience. 26:107070107070
- Miyake, A., Ohmori, T., Murakawa, Y. (2023) Fgf22 and Fgfr2b are required for neurogenesis and gliogenesis in the zebrafish forebrain. Biochemical and Biophysical Research Communications. 681:212217212-217
- Zhang, T., Alonzo, I., Stubben, C., Geng, Y., Herdman, C., Chandler, N., Doane, K.P., Pluimer, B.R., Trauger, S.A., Peterson, R.T. (2023) A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. Disease models & mechanisms. 16(7):
- Fontenas, L., Kucenas, S. (2021) Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia. eLIFE. 10:
- Raas, Q., van de Beek, M.C., Forss-Petter, S., Dijkstra, I.M., DeSchiffart, A., Freshner, B.C., Stevenson, T.J., Jaspers, Y.R., Nagtzaam, L.M., Wanders, R.J., van Weeghel, M., Engelen-Lee, J.Y., Engelen, M., Eichler, F., Berger, J., Bonkowsky, J.L., Kemp, S. (2021) Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. The Journal of Clinical Investigation. 131(8):
- El-Nachef, W.N., Bronner, M.E. (2020) De novo enteric neurogenesis in post-embryonic zebrafish from Schwann cell precursors rather than resident cell types. Development (Cambridge, England). 147(13):
- Marisca, R., Hoche, T., Agirre, E., Hoodless, L.J., Barkey, W., Auer, F., Castelo-Branco, G., Czopka, T. (2020) Functionally distinct subgroups of oligodendrocyte precursor cells integrate neural activity and execute myelin formation. Nature Neuroscience. 23(3):363-374
- Tambalo, M., Mitter, R., Wilkinson, D.G. (2020) A single cell transcriptome atlas of the developing zebrafish hindbrain. Development (Cambridge, England). 147(6):
- Zhang, T., Guan, P., Liu, W., Zhao, G., Fang, Y., Fu, H., Gui, J.F., Li, G., Liu, J.X. (2020) Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation. Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(10):194612
- Nagarajan, B., Harder, A., Japp, A., Häberlein, F., Mingardo, E., Kleinert, H., Yilmaz, Ö., Zoons, A., Rau, B., Christ, A., Kubitscheck, U., Eiberger, B., Sandhoff, R., Eckhardt, M., Hartmann, D., Odermatt, B. (2019) CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 68(3):509-527
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