Gene
dhrs12la
- ID
- ZDB-GENE-030131-8104
- Name
- dehydrogenase/reductase 12-like a
- Symbol
- dhrs12la Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Acts upstream of or within with a positive effect on positive regulation of oligodendrocyte differentiation. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human DHRS12 (dehydrogenase/reductase 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 6 figures from Nagarajan et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | NAD(P)-binding domain superfamily | Short-chain dehydrogenase/reductase SDR | Short-chain dehydrogenases/reductases member 12 |
|---|---|---|---|---|
|
UniProtKB:Q6W2N6
|
320 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dhrs12la-201
(1)
|
Ensembl | 3,341 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-dhrs12la | polyclonal | Rabbit |
|
1 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | fj52f06 | ||
| Encodes | EST | fq25e07 | Rauch et al., 2003 | |
| Encodes | cDNA | MGC:136710 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_203511 (1) | 1693 nt | ||
| Genomic | GenBank:FO704834 (1) | 103120 nt | ||
| Polypeptide | UniProtKB:Q6W2N6 (1) | 320 aa |
- Brown, T.L., Hashimoto, H., Finseth, L.T., Wood, T.L., Macklin, W.B. (2021) PAK1 positively regulates oligodendrocyte morphology and myelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(9):1864-1877
- Nagarajan, B., Harder, A., Japp, A., Häberlein, F., Mingardo, E., Kleinert, H., Yilmaz, Ö., Zoons, A., Rau, B., Christ, A., Kubitscheck, U., Eiberger, B., Sandhoff, R., Eckhardt, M., Hartmann, D., Odermatt, B. (2019) CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 68(3):509-527
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kearns, C.A., Ravanelli, A.M., Cooper, K., Appel, B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14861-71
- Gebriel, M., Prabhudesai, S., Uleberg, K.E., Larssen, E., Piston, D., Bjørnstad, A.H., Møller, S.G. (2014) Zebrafish brain proteomics reveals central proteins involved in neurodegeneration. Journal of neuroscience research. 92(1):104-15
- Mathews, E.S., Mawdsley, D.J., Walker, M., Hines, J.H., Pozzoli, M., Appel, B. (2014) Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:3402-12
- Zhao, S., Cui, W.Y., Cao, J., Luo, C., Fan, L., and Li, M.D. (2014) Impact of Maternal Nicotine Exposure on Expression of Myelin-Related Genes in Zebrafish Larvae. Zebrafish. 11(1):10-6
- Simmons, T., and Appel, B. (2012) Mutation of pescadillo Disrupts Oligodendrocyte Formation in Zebrafish. PLoS One. 7(2):e32317
- Singh, S.K., Sundaram, C.S., Shanbhag, S., and Idris, M.M. (2010) Proteomic profile of zebrafish brain based on two-dimensional gel electrophoresis matrix-assisted laser desorption/ionization MS/MS analysis. Zebrafish. 7(2):169-177
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