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Phenotype Figure Summary
Marker:
vps16
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
Banerjee
et al.
, 2024
Fig. 1
vps16
wsu4/wsu4
(AB)
forebrain nucleus condensed, abnormal
integument decreased pigmentation, abnormal
photoreceptor outer segment layer truncated, abnormal
retina degenerate, abnormal
retina nucleus condensed, abnormal
retinal pigmented epithelium decreased pigmentation, abnormal
whole organism dead, abnormal
whole organism semi-viable, abnormal
Fig. 2
vps16
wsu4/wsu4
(AB)
long double cone cell cytoplasm zpr-1 labeling increased distribution, abnormal
Muller cell reactive gliosis increased process quality, abnormal
retina apoptotic process increased process quality, abnormal
retinal rod cell rod photoreceptor outer segment decreased length, abnormal
retinal rod cell rod photoreceptor outer segment zpr-3 labeling decreased distribution, abnormal
short double cone cell cytoplasm zpr-1 labeling increased distribution, abnormal
Fig. 3
vps16
wsu4/wsu4
(AB)
forebrain apoptotic process increased process quality, abnormal
hindbrain apoptotic process increased process quality, abnormal
hindbrain myelination decreased process quality, abnormal
midbrain apoptotic process increased process quality, abnormal
midbrain myelination decreased process quality, abnormal
Fig. 4
vps16
wsu4/wsu4
(AB)
swimming behavior decreased process quality, abnormal
Sofou
et al.
, 2021
Figure 7
ue2Tg + CRISPR1-vps16
, 
AB + CRISPR1-vps16
brain myelin sheath EGFP expression decreased amount, abnormal
eye translucent, abnormal
head melanocyte morphology, abnormal
hindbrain myelination disrupted, abnormal
integument decreased pigmentation, abnormal
midbrain myelination disrupted, abnormal
retinal pigmented epithelium decreased pigmentation, abnormal
swim bladder aplastic, abnormal
Figure 8
re10Tg + CRISPR1-vps16
, 
AB + CRISPR1-vps16
, 
gl22Tg + CRISPR1-vps16
astrocyte lysosome increased amount, abnormal
brain lysosome increased amount, abnormal
lysosome organization disrupted, abnormal
microglial cell lysosome increased amount, abnormal
microglial cell morphology, abnormal
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