Publication	Data		Fish	Anatomy
Armistead et al., 2020	Fig. 6		s1pr2te273/te273	caudal fin epidermal cell aggregated, abnormal
Wu et al., 2018	Fig. 1		twu34Tg + CRISPR6-s1pr2 ,   twu34Tg + CRISPR7-s1pr2 ,   twu34Tg + CRISPR8-s1pr2 ,   twu34Tg + CRISPR5-s1pr2 ,   twu34Tg + CRISPR5-s1pr2 + CRISPR6-s1pr2 + CRISPR7-s1pr2 + CRISPR8-s1pr2	cardioblast migration to the midline involved in heart field formation decreased occurrence, abnormal
Xie et al., 2016	Fig. 1		is5Tg; ui6Tg + MO1-s1pr2 ,   s1pr2m93/m93	endocardium mislocalised, abnormal endocardium unfused from endocardium, abnormal
Burczyk et al., 2015	Fig. 7		s1pr2m93/m93	heart rudiment formation decreased process quality, abnormal heart rudiment split, abnormal
Gu et al., 2015	Fig. 1		s1pr2m93/m93	epidermal cell aggregated, abnormal
	Fig. 7		WT + MO1-s1pr2	epidermal cell aggregated, abnormal
Hisano et al., 2015	Fig. 3		s1pr2ko322/ko322	heart duplicated, abnormal heart morphogenesis process quality, abnormal heart shape, abnormal heart split bilaterally, abnormal
	Fig. 6		s1pr2ko322/ko322	heart duplicated, abnormal heart morphogenesis process quality, abnormal heart shape, abnormal heart split bilaterally, abnormal
	Fig. 9		s1pr2ko322/ko322	median fin blistered, abnormal
Hisano et al., 2015	Fig. 3		s1pr2ko322/ko322	heart tube duplicated, abnormal
	Fig. 5		s1pr2ko322/ko322	splanchnocranium bone mineralization disrupted, abnormal ventral mandibular arch anterior-posterior axis decreased length, abnormal ventral mandibular arch morphology, abnormal
Mendelson et al., 2015	Fig. 3		s1pr2m93/m93	cell migration to the midline involved in heart development decreased occurrence, abnormal embryonic heart tube formation decreased occurrence, abnormal heart edematous, abnormal heart tube split bilaterally, abnormal post-vent region epithelium blistered, abnormal
Fukui et al., 2014	Fig. 1		AB + MO1-s1pr2 ,   ncv10Tg + MO1-s1pr2	cardiac muscle progenitor cell migration to the midline involved in heart field formation decreased occurrence, abnormal heart malformed, abnormal heart morphogenesis decreased process quality, abnormal heart split bilaterally, abnormal heart tube split bilaterally, abnormal myocardial precursor mislocalised laterally, abnormal
	Fig. 2		AB + MO1-s1pr2 ,   ha01Tg; ncv11Tg + MO1-s1pr2	cardiac muscle progenitor cell migration to the midline involved in heart field formation decreased occurrence, abnormal endoderm antero-medial region decreased object quality, abnormal heart morphogenesis decreased process quality, abnormal heart tube split bilaterally, abnormal myocardial precursor mislocalised laterally, abnormal pharyngeal endoderm mislocalised laterally, abnormal
	Fig. 3		ha01Tg + MO1-s1pr2 ,   s1pr2m93/m93	cardiac muscle progenitor cell migration to the midline involved in heart field formation decreased occurrence, abnormal endoderm anterior region apoptotic, abnormal endoderm apoptotic process increased occurrence, abnormal heart morphogenesis decreased process quality, abnormal heart tube split bilaterally, abnormal
Nakanaga et al., 2014	Fig. 3		AB/TU + MO1-s1pr2	embryonic heart tube morphogenesis disrupted, abnormal
Hisano et al., 2013	Fig. S3		ko07Tg + TALEN1-s1pr2 ,   WT + MO1-s1pr2	heart tube bifurcated, abnormal
Hisano et al., 2013	Fig. 3		s1pr2ko322/ko322 ,   s1pr2ko322/ko322; ko07Tg	cardioblast migration to the midline involved in heart rudiment formation decreased process quality, abnormal cardioblast migration to the midline involved in heart rudiment formation disrupted, abnormal heart tube increased amount, abnormal heart tube mislocalised laterally, abnormal pharyngeal arch 1 decreased length, abnormal
	Fig. S1		ko07Tg + MO1-s1pr2 ,   WT + MO1-s1pr2	cardioblast migration to the midline involved in heart rudiment formation decreased process quality, abnormal cardioblast migration to the midline involved in heart rudiment formation disrupted, abnormal heart tube increased amount, abnormal heart tube mislocalised laterally, abnormal pharyngeal arch 1 decreased length, abnormal pharyngeal arch 1 morphology, abnormal
Hu et al., 2013	Fig. 2		WT + MO1-s1pr2	otic vesicle morphogenesis disrupted, abnormal otolith increased size, abnormal otolith malformed, abnormal saccule decreased size, abnormal semicircular canal broken into two pieces, abnormal semicircular canal development disrupted, abnormal semicircular canal morphology, abnormal utricle increased size, abnormal
	Fig. 3		WT + MO1-s1pr2	anterior lateral line neuromast hair cell decreased amount, abnormal anterior lateral line neuromast hair cell development disrupted, abnormal posterior lateral line has fewer parts of type posterior lateral line neuromast, abnormal posterior lateral line neuromast decreased size, abnormal posterior lateral line neuromast hair cell development disrupted, abnormal
	Fig. 5		WT + MO1-s1pr2	neuromast hair cell apoptotic, abnormal
Ye et al., 2013	Fig. 1		WT + MO1-s1pr2 ,   twu34Tg + MO1-s1pr2	caudal fin blistered, abnormal heart duplicated, abnormal pericardium edematous, abnormal
	Fig. 2		WT + MO1-s1pr2	heart duplicated, abnormal
	Fig. 5		s1pr2m93/m93; ha01Tg	endoderm anterior region increased width, abnormal endoderm anterior region perforate, abnormal
	Fig. 6		s1pr2m93/m93; ha01Tg	endoderm convergent extension process quality, abnormal
	Fig. 7		ha01Tg; twu34Tg + MO1-s1pr2	endoderm anterior region increased width, abnormal endoderm anterior region perforate, abnormal heart duplicated, abnormal
Balczerski et al., 2012	Fig. 1		s1pr2m93/m93	ethmoid cartilage hypoplastic, abnormal mandibular arch skeleton hypoplastic, abnormal mandibular arch skeleton mislocalised, abnormal Meckel's cartilage aplastic, abnormal Meckel's cartilage disorganized, abnormal Meckel's cartilage hypoplastic, abnormal Meckel's cartilage malformed, abnormal neurocranial trabecula hypoplastic, abnormal palatoquadrate cartilage aplastic, abnormal
	Fig. 3		s1pr2m93/m93	oral ectoderm disorganized, abnormal oral ectoderm hypoplastic, abnormal oral ectoderm mislocalised anteriorly, abnormal pharyngeal ectoderm disorganized, abnormal pharyngeal ectoderm increased area, abnormal pharyngeal endoderm disorganized, abnormal pharyngeal endoderm mislocalised posteriorly, abnormal
	Fig. 5		s1pr2m93/m93	mandibular arch skeleton shape, abnormal mandibular arch skeleton size, abnormal
Garnaas et al., 2012	Fig. s3		s1pr2m93/m93	heart tube duplicated, abnormal liver bilateral, abnormal
Kawahara et al., 2009	Fig. S11		WT + MO1-s1pr2	heart bifurcated, abnormal
	Fig. S4		ko07Tg + MO1-s1pr2 ,   WT + MO1-s1pr2	caudal fin blistered, abnormal heart bifurcated, abnormal
Kai et al., 2008	Fig. 1		WT + MO1-s1pr2	cell migration involved in gastrulation disrupted, abnormal mesodermal cell migration increased rate, abnormal prechordal plate flat, abnormal prechordal plate increased length, abnormal prechordal plate increased width, abnormal
	Fig. S3		WT + MO1-s1pr2	cell migration involved in gastrulation disrupted, abnormal neural keel increased length, abnormal
	Fig. S4		WT + MO1-s1pr2	hypoblast mesodermal cell spatial pattern, abnormal
Osborne et al., 2008	Fig. 1		s1pr2m93/m93	blood circulation disrupted, abnormal caudal fin endoderm blistered, abnormal heart edematous, abnormal heart rudiment bifurcated, abnormal
Serluca, 2008	Fig. 5		WT + MO2-s1pr2	heart cleft, abnormal
Holtzman et al., 2007	Fig. 3		s1pr2te273/te273	heart rudiment malformed, abnormal
Matsui et al., 2007	Fig. 2		s1pr2te273/te273; twu34Tg/twu34Tg	heart bifurcated, abnormal heart increased amount, abnormal heart morphogenesis disrupted, abnormal
Phenotype Annotation (1994-2006)	Fig. for (m93)		s1pr2m93/m93	anatomical system quality, abnormal heart quality, abnormal whole organism lethal (sensu genetics), abnormal
	Fig. for (te273)		s1pr2te273/te273	anatomical system quality, abnormal heart quality, abnormal whole organism lethal (sensu genetics), abnormal
Chen et al., 1996	Fig. 1		s1pr2te273/te273	blood circulation arrested, abnormal caudal fin blistered, abnormal heart duplicated, abnormal heart morphogenesis disrupted, abnormal heart tube duplicated, abnormal pericardium swollen, abnormal
	Table 1		s1pr2m93/m93	heart morphogenesis disrupted, abnormal heart tube duplicated, abnormal
Stainier et al., 1996	Fig. 3		s1pr2m93/m93	blood circulation arrested, abnormal heart tube bifurcated, abnormal heart tube duplicated, abnormal