Genomic Feature
s718
- ID
- ZDB-ALT-210223-2
- Name
- s718
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Stainier Lab
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 25: 29181155 - 29181165 (GRCz11) (1) Details
- Nucleotide change
- GGGCGTGGACA/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 11 bp deleted in Exon 4 (1)
- Transcript Consequence
- None
- Protein Consequence
- None
- Flanking Sequence
-
ACATATGCTGGATAAGTTAGCAGTTTATTCTGGTATGGCAACCCCAGATTCATAAAGGGACTAAGCCGAAAAGAAAATGAATGAATGAATAATAAGTTGGCTTTTAACACTCAATGGATAAACTTTGAGTATAATATCTCCTCATTGCACACAGTTGTTTATGTTGGTCATATCATTTTTGTAATTGAGTTACTCGCATAATTCAAGAAAAGTGTCACAAAGGGGCACAAGAAAAGAGTAGATAATATACAGTATATACATATATATATATATATATATATATATATATATATATATAAAATTATTTCAAAATGCAAGGACTGACAAAAACCAATTGTCTTAATGTTTCCAATTGTTCCAGGATCTGACTTCCTGAACTGTGAGATTGAGAACGGAGGCATGTTGGGCAGCAAGAAAGGTGTGAACCTGCCTGGAGCCAATGTTGACCTGCCCGCAGTGTCTGAGAAGGACATCAAGGACCTTCAGTTTGGTGTGGAACA
GGGCGTGGACA/- TGGTTTTTGCCTCCTTTATCCGCAAAGCTGCTGATGTGCACGCTGTCAGGAAGGTGCTCGGAGAGAAAGGGAAGGATATCAGGATCATCAGTAAGCTGGAGAACCATGAGGGTGTGCGCAAGTGAGTGAAGAAATAAAAAAAGATTCTTGTATCAGTATTACAGTATTATACATACTATTGAATATTTATTTATAGTATTGATTAAATAGTATGCATAATTTTTACTTATAAATGTATAAAATGCTACATATGTGTGTATTTATAAGTATATACATGTTGCAGCATAGGCTCATTCTGAAAACGTAGCTCTATATACATTTCCAACCCAGGCTCATTCTGAAAACGTAGTCCAGCGGACGTTTCTGGAGACCTCGAAATATATCCCGGGAGGTACGTATTTGTGCAGTTTTTATTTTCGCGAATCTGCGAGAGGCCGCTGTGCGTGCTTTTTTGTATCTCGAACGTCTCTCGCGAGTGCCGTTCGCACCCGCGCTGTTCT - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| pkmas717/s717; pkmbs718/s718; s843Tg | Complex | 2 figures from Stone et al., 2018 | |||
| pkmas717/s717; pkmbs718/+ | Complex | Fig. 2 from Fukuda et al., 2020 | |||
| pkmas717/+; pkmbs718/+ | Complex |
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Supplemental Information
- Genotyping protocol
- None
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Fukuda, R., Aharonov, A., Ong, Y.T., Stone, O.A., El-Brolosy, M., Maischein, H.M., Potente, M., Tzahor, E., Stainier, D.Y. (2019) Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. eLIFE. 8:
- Stone, O.A., El-Brolosy, M., Wilhelm, K., Liu, X., Romão, A.M., Grillo, E., Lai, J.K.H., Günther, S., Jeratsch, S., Kuenne, C., Lee, I.C., Braun, T., Santoro, M.M., Locasale, J.W., Potente, M., Stainier, D.Y.R. (2018) Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature communications. 9:4077
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