Gene
pkmb
- ID
- ZDB-GENE-040801-230
- Name
- pyruvate kinase M1/2b
- Symbol
- pkmb Nomenclature History
- Previous Names
-
- pkm2b
- zgc:92037 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable pyruvate kinase activity. Involved in sprouting angiogenesis. Predicted to be active in cytoplasm. Is expressed in cardiac ventricle; male organism; myotome; and pectoral fin musculature. Orthologous to human PKM (pyruvate kinase M1/2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92037 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| s718 | Allele with one deletion | Exon 4 | Unknown | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Pyruvate kinase | Pyruvate kinase, active site | Pyruvate kinase, barrel | Pyruvate kinase, C-terminal | Pyruvate kinase, C-terminal domain superfamily | Pyruvate kinase, insert domain superfamily | Pyruvate kinase-like domain superfamily | Pyruvate kinase-like, insert domain superfamily | Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BA79
|
605 | |||||||||
|
UniProtKB:Q6DG54
|
530 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-67P11 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-74B4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92037 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192798 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003488 (1) | 1955 nt | ||
| Genomic | GenBank:CR376821 (1) | 164689 nt | ||
| Polypeptide | UniProtKB:A0A8M2BA79 (1) | 605 aa |
- Zuppo, D.A., Missinato, M.A., Santana-Santos, L., Li, G., Benos, P.V., Tsang, M. (2023) Foxm1 regulates cardiomyocyte proliferation in adult zebrafish after cardiac injury. Development (Cambridge, England). 150(6):
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Zhang, Y., Jiao, Y., Tao, Y., Li, Z., Yu, H., Han, S., Yang, Y. (2021) Monobutyl phthalate can induce autophagy and metabolic disorders by activating the ire1a-xbp1 pathway in zebrafish liver. Journal of hazardous materials. 412:125243
- Fukuda, R., Marín-Juez, R., El-Sammak, H., Beisaw, A., Ramadass, R., Kuenne, C., Guenther, S., Konzer, A., Bhagwat, A.M., Graumann, J., Stainier, D.Y. (2020) Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO reports. 21(8):e49752
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
- Fukuda, R., Aharonov, A., Ong, Y.T., Stone, O.A., El-Brolosy, M., Maischein, H.M., Potente, M., Tzahor, E., Stainier, D.Y. (2019) Metabolic modulation regulates cardiac wall morphogenesis in zebrafish. eLIFE. 8:
- Houbrechts, A.M., Beckers, A., Vancamp, P., Sergeys, J., Gysemans, C., Mathieu, C., Darras, V.M. (2019) Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish. Endocrinology. 160(11):2759-2772
- Wang, Z., Ding, Z.C., Xu, Q.H., Liu, J.X. (2019) Metabolism responses to silver nanoparticles stresses during zebrafish embryogenesis. Elsevier Science. 222:991-1002
- Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312
- Stone, O.A., El-Brolosy, M., Wilhelm, K., Liu, X., Romão, A.M., Grillo, E., Lai, J.K.H., Günther, S., Jeratsch, S., Kuenne, C., Lee, I.C., Braun, T., Santoro, M.M., Locasale, J.W., Potente, M., Stainier, D.Y.R. (2018) Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells. Nature communications. 9:4077
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