ZFIN Morpholino: MO1-tardbpb

Target Location

Genome Build: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tardbpb

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Phenotype

Phenotype resulting from MO1-tardbpb

Phenotype	Fish	Figures
acetylcholinesterase activity decreased process quality, abnormal	WT + MO1-tardbpb	Figure 2 from Campanari et al., 2021
axon extension process quality, abnormal	ml2Tg + MO1-tardbpb	Fig. 4 from Chitramuthu et al., 2017
CaP motoneuron axon decreased length, abnormal	ml2Tg + MO1-tardbpb	Fig. 4 , Fig. 5 from Chitramuthu et al., 2017
locomotory behavior disrupted, abnormal	WT + MO1-tardbpb	Figure 3 from Campanari et al., 2021 Fig. 4, Fig. 5 from Kabashi et al., 2010
locomotory behavior having decreased processual parts skeletal muscle contraction, abnormal	WT + MO1-tardbpb	Fig. 4, Fig. 5 from Kabashi et al., 2010

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Phenotype of all Fish created by or utilizing MO1-tardbpb

Phenotype	Fish	Conditions	Figures
skeletal muscle acetylcholine-gated channel clustering disrupted, abnormal	WT + MO1-tardbpb	standard conditions	Figure 1 from Campanari et al., 2021
locomotory behavior having decreased processual parts skeletal muscle contraction, abnormal	WT + MO1-tardbpb	standard conditions	Fig. 4, Fig. 5 from Kabashi et al., 2010
motor neuron axon decreased length, abnormal	WT + MO1-tardbpb	standard conditions	Fig. 6 from Kabashi et al., 2011
whole organism chrna1 expression increased amount, abnormal	WT + MO1-tardbpb	standard conditions	Figure 1 from Campanari et al., 2021
locomotory behavior disrupted, abnormal	WT + MO1-tardbpb	standard conditions	Figure 3 from Campanari et al., 2021 Fig. 4, Fig. 5 from Kabashi et al., 2010

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Citations

Include unpublished citations

Campanari, M.L., Marian, A., Ciura, S., Kabashi, E. (2021) TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish. Cells. 10(2):
Demy, D.L., Campanari, M.L., Munoz-Ruiz, R., Durham, H.D., Gentil, B.J., Kabashi, E. (2020) Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish. Cells. 9(5):
Chitramuthu, B.P., Kay, D.G., Bateman, A., Bennett, H.P. (2017) Neurotrophic effects of progranulin in vivo in reversing motor neuron defects caused by over or under expression of TDP-43 or FUS. PLoS One. 12:e0174784
Hao, L.T., Wolman, M., Granato, M., and Beattie, C.E. (2012) Survival motor neuron affects plastin 3 protein levels leading to motor defects. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(15):5074-5084
Kabashi, E., Bercier, V., Lissouba, A., Liao, M., Brustein, E., Rouleau, G.A, and Drapeau, P. (2011) FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis. PLoS Genetics. 7(8):e1002214
Kabashi, E., Lin, L., Tradewell, M.L., Dion, P.A., Bercier, V., Bourgouin, P., Rochefort, D., Bel Hadj, S., Durham, H.D., Vande Velde, C., Rouleau, G.A., and Drapeau, P. (2010) Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Human molecular genetics. 19(4):671-683

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