Gene
tardbpb
- ID
- ZDB-GENE-030131-3777
- Name
- TAR DNA binding protein b
- Symbol
- tardbpb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within several processes, including axon extension; neuromuscular junction development; and regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in several structures, including brain; eye; gill; heart; and liver. Used to study amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu466 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 14 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh301 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| mde150 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde198 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde201 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde897 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde909 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | zinc finger nuclease | |
| mde948 | Allele with one deletion | Exon 6 | Frameshift, Premature Stop | zinc finger nuclease | |
| mg1Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| nkz3 | Allele with one deletion | Unknown | Premature Stop | CRISPR | |
| sa40778 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| amyotrophic lateral sclerosis type 10 | Alliance | Amyotrophic lateral sclerosis 10, with or without FTD | 612069 |
| amyotrophic lateral sclerosis type 10 | Alliance | Frontotemporal lobar degeneration, TARDBP-related | 612069 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| amyotrophic lateral sclerosis | WT + MO1-tardbpb | standard conditions | (2) |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR041105 | TAR DNA-binding protein 43, N-terminal |
| Domain | IPR049124 | TAR DNA-binding protein 43, C-terminal |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | Nucleotide-binding alpha-beta plait domain superfamily | RNA-binding domain superfamily | RNA recognition motif domain | TAR DNA-binding protein 43, C-terminal | TAR DNA-binding protein 43, N-terminal |
|---|---|---|---|---|---|---|
|
UniProtKB:Q802C7
|
412 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tardbp-201
(1)
|
Ensembl | 2,798 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-tardbp | polyclonal | Rabbit |
|
Proteintech
|
4 | ||
| Ab5-tardbp | monoclonal | IgG2a | Rat |
|
4 | ||
| Ab3-tardbp | polyclonal | Rabbit |
|
Novus Biologicals, LLC
|
2 | ||
| Ab6-tardbp | polyclonal | Rabbit |
|
Sigma-Aldrich
|
4 |
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Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-148L2 | ZFIN Curated Data | |
| Encodes | EST | eu466 | Thisse et al., 2005 | |
| Encodes | EST | fb77f02 | ||
| Encodes | EST | fc52g10 | ||
| Encodes | cDNA | MGC:55939 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_201476 (1) | 2787 nt | ||
| Genomic | GenBank:BX663614 (1) | 191715 nt | ||
| Polypeptide | UniProtKB:Q802C7 (1) | 412 aa |
- Hu, Y., Hruscha, A., Pan, C., Schifferer, M., Schmidt, M.K., Nuscher, B., Giera, M., Kostidis, S., Burhan, Ö., van Bebber, F., Edbauer, D., Arzberger, T., Haass, C., Schmid, B. (2024) Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits. Molecular neurodegeneration. 19:5050
- Asakawa, K., Handa, H., Kawakami, K. (2023) Dysregulated TDP-43 proteostasis perturbs excitability of spinal motor neurons during brainstem-mediated fictive locomotion in zebrafish. Development, growth & differentiation. 65(8):446-452
- Hipke, K., Pitter, B., Hruscha, A., van Bebber, F., Modic, M., Bansal, V., Lewandowski, S.A., Orozco, D., Edbauer, D., Bonn, S., Haass, C., Pohl, U., Montanez, E., Schmid, B. (2023) Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Frontiers in cell and developmental biology. 11:11699621169962
- Asakawa, K., Handa, H., Kawakami, K. (2022) Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae. Journal of visualized experiments : JoVE. (180):
- Légaré, V.P., Rampal, C.J., Gurberg, T.J.N., Harji, Z.A., Allard-Chamard, X., Rodríguez, E.C., Armstrong, G.A.B. (2022) Development of an endogenously myc-tagged TARDBP (TDP-43) zebrafish model using the CRISPR/Cas9 system and homology directed repair. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 261:110756
- Quelle-Regaldie, A., Folgueira, M., Yáñez, J., Sobrido-Cameán, D., Alba-González, A., Barreiro-Iglesias, A., Sobrido, M.J., Sánchez, L. (2022) A nop56 Zebrafish Loss-of-Function Model Exhibits a Severe Neurodegenerative Phenotype. Biomedicines. 10(8)
- Campanari, M.L., Marian, A., Ciura, S., Kabashi, E. (2021) TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish. Cells. 10(2):
- Asakawa, K., Handa, H., Kawakami, K. (2020) Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons. Nature communications. 11:1004
- Bourefis, A.R., Campanari, M.L., Buee-Scherrer, V., Kabashi, E. (2020) Functional characterization of a FUS mutant zebrafish line as a novel genetic model for ALS. Neurobiology of disease. 142:104935
- Demy, D.L., Campanari, M.L., Munoz-Ruiz, R., Durham, H.D., Gentil, B.J., Kabashi, E. (2020) Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish. Cells. 9(5):
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