Gene
hdac4
- ID
- ZDB-GENE-061013-95
- Name
- histone deacetylase 4
- Symbol
- hdac4 Nomenclature History
- Previous Names
-
- wu:fa96d08
- wu:fc56f08
- zgc:152701
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have NAD-dependent histone deacetylase activity (H3-K14 specific) and metal ion binding activity. Involved in animal organ development; perichondral ossification; and regulation of neural crest formation. Predicted to localize to histone deacetylase complex. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Is expressed in several structures, including cranial neural crest cell; cranium; nervous system; optic vesicle; and trigeminal placode. Orthologous to human HDAC4 (histone deacetylase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017636 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with central hypotonia and dysmorphic facies | 619797 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR023801 | Histone deacetylase domain |
| Domain | IPR024643 | Histone deacetylase, glutamine rich N-terminal domain |
| Family | IPR000286 | Histone deacetylase family |
| Family | IPR046949 | Histone deacetylase 4/5/7/9 |
| Homologous_superfamily | IPR023696 | Ureohydrolase domain superfamily |
| Homologous_superfamily | IPR037138 | Histone deacetylase domain superfamily |
Domain Details Per Protein
| Protein | Length | Histone deacetylase 4/5/7/9 | Histone deacetylase domain | Histone deacetylase domain superfamily | Histone deacetylase family | Histone deacetylase, glutamine rich N-terminal domain | Ureohydrolase domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IAH0
|
1052 | ||||||
|
UniProtKB:Q08BS8
|
1023 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-hdac4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available