ZFIN Morpholino: MO1-ift172

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ift172

Expressed Gene	Anatomy	Figures
ptch2	neural tube somite	Fig. 9 from Lunt et al., 2009

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Phenotype

Phenotype resulting from MO1-ift172

Phenotype	Fish	Figures
cilium assembly disrupted, abnormal	WT + MO1-ift172	Fig. 2 from Lunt et al., 2009
neural tube axoneme absent, abnormal	WT + MO1-ift172	Fig. 2 from Lunt et al., 2009
otic vesicle decreased size, abnormal	WT + MO1-ift172	Fig. 2 from Lunt et al., 2009
otic vesicle cilium decreased amount, abnormal	WT + MO1-ift172	Fig. 2 from Lunt et al., 2009
otic vesicle cilium decreased length, abnormal	WT + MO1-ift172	Fig. 2 from Lunt et al., 2009

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Phenotype of all Fish created by or utilizing MO1-ift172

Phenotype	Fish	Conditions	Figures
trunk curved ventral, abnormal	AB/TU + MO1-ift172	standard conditions	Fig. 7 from Li et al., 2011
cilium assembly disrupted, abnormal	WT + MO1-ift172	standard conditions	Fig. 2 from Lunt et al., 2009
neural tube axoneme absent, abnormal	WT + MO1-ift172	standard conditions	Fig. 2 from Lunt et al., 2009
post-vent region curved ventral, abnormal	WT + MO1-ift172	standard conditions	Fig. 3 from Dibella et al., 2009
otic vesicle cilium decreased amount, abnormal	WT + MO1-ift172	standard conditions	Fig. 2 from Lunt et al., 2009

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Citations

Include unpublished citations

Zhao, L., Yuan, S., Cao, Y., Kallakuri, S., Li, Y., Kishimoto, N., Dibella, L., and Sun, Z. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proceedings of the National Academy of Sciences of the United States of America. 110(31):12697-702
Li, J., and Sun, Z. (2011) Qilin is essential for cilia assembly and normal kidney development in zebrafish. PLoS One. 6(11):e27365
Cao, Y., Park, A., and Sun, Z. (2010) Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity. Journal of the American Society of Nephrology : JASN. 21(8):1326-1333
Dibella, L.M., Park, A., and Sun, Z. (2009) Zebrafish Tsc1 Reveals Functional Interactions Between the Cilium and the TOR Pathway. Human molecular genetics. 18(4):595-606
Lunt, S.C., Haynes, T., and Perkins, B.D. (2009) Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(7):1744-1759
Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S. and Hopkins, N. (2004) A Genetic Screen in Zebrafish Identifies Cilia Genes as a Principal Cause of Cystic Kidney Development. Development (Cambridge, England). 131(16):4085-4093

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