Gene

ift172

ID

ZDB-GENE-040827-1

Name

intraflagellar transport 172

Symbol

ift172 Nomenclature History

Previous Names

moe (1)
LIM-interacting protein (1)

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Involved in several processes, including animal organ development; photoreceptor cell maintenance; and regulation of TOR signaling. Predicted to localize to axoneme; ciliary basal body; and intraciliary transport particle B. Used to study cystic kidney disease. Human ortholog(s) of this gene implicated in retinitis pigmentosa 71 and short-rib thoracic dysplasia 10 with or without polydactyly. Orthologous to human IFT172 (intraflagellar transport 172).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhu et al., 2021

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 17 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ift172 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 20	Alliance	Bardet-Biedl syndrome 20	619471
retinitis pigmentosa 71	Alliance	Retinitis pigmentosa 71	616394
short-rib thoracic dysplasia 10 with or without polydactyly	Alliance	Short-rib thoracic dysplasia 10 with or without polydactyly	615630

Associated With ift172 Via Experimental Models

Human Disease	Fish	Conditions	Citations
cystic kidney disease	li1Tg + MO3-ift172	control	Pandey et al., 2019
polycystic kidney disease	ift172^{hi2211Tg/hi2211Tg} (AB/TU)	standard conditions	Cao et al., 2009

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat