ZFIN Morpholino: MO2-foxj1a

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-foxj1a

Expressed Gene	Anatomy	Figures
cetn4	(not) floor plate (not) forerunner cell group (not) pronephric duct	Fig. 3 from Yu et al., 2008
dnah9	(not) floor plate (not) forerunner cell group (not) pronephric duct	Fig. 3 from Yu et al., 2008
nkx2.9	floor plate cilium	Fig. S3 from Yu et al., 2008
pax2a	pronephric duct	Fig. S3 from Yu et al., 2008
rfx2	neural tube pronephric duct	Fig. S6 from Yu et al., 2008

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Phenotype

Phenotype resulting from MO2-foxj1a

Phenotype	Fish	Figures
determination of heart left/right asymmetry disrupted, abnormal	WT + MO2-foxj1a	Fig. 4 from Dutta et al., 2015
determination of left/right symmetry arrested, abnormal	WT + MO2-foxj1a	Fig. S3 from Yu et al., 2008
determination of left/right symmetry disrupted, abnormal	WT + MO2-foxj1a	Fig. 4 from Dutta et al., 2015
floor plate cilium decreased amount, abnormal	WT + MO2-foxj1a	Fig. 2 from Yu et al., 2008
heart bilateral symmetry, abnormal	WT + MO2-foxj1a	Fig. S3 from Yu et al., 2008

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Phenotype of all Fish created by or utilizing MO2-foxj1a

Phenotype	Fish	Conditions	Figures
Kupffer's vesicle znf703 expression amount, ameliorated	WT + MO2-foxj1a	chemical treatment: lithium chloride	Fig. 4 from Dutta et al., 2015
Kupffer's vesicle motile cilium absent, abnormal	WT + MO2-foxj1a	standard conditions	Fig. 4 from Dutta et al., 2015
heart looping disrupted, abnormal	WT + MO2-foxj1a	standard conditions	Fig. S3 from Yu et al., 2008
whole organism posterior region znf703 expression amount, ameliorated	WT + MO2-foxj1a	chemical treatment: lithium chloride	Fig. 4 from Dutta et al., 2015
pronephric duct cilium decreased amount, abnormal	WT + MO2-foxj1a	standard conditions	Fig. 2 from Yu et al., 2008

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Citations

Include unpublished citations

Szenker-Ravi, E., Ott, T., Khatoo, M., de Bellaing, A.M., Goh, W.X., Chong, Y.L., Beckers, A., Kannesan, D., Louvel, G., Anujan, P., Ravi, V., Bonnard, C., Moutton, S., Schoen, P., Fradin, M., Colin, E., Megarbane, A., Daou, L., Chehab, G., Di Filippo, S., Rooryck, C., Deleuze, J.F., Boland, A., Arribard, N., Eker, R., Tohari, S., Ng, A.Y., Rio, M., Lim, C.T., Eisenhaber, B., Eisenhaber, F., Venkatesh, B., Amiel, J., Crollius, H.R., Gordon, C.T., Gossler, A., Roy, S., Attie-Bitach, T., Blum, M., Bouvagnet, P., Reversade, B. (2021) Discovery of a genetic module essential for assigning left-right asymmetry in humans and ancestral vertebrates. Nature Genetics. 54(1):62-72
Ribeiro, A., Monteiro, J.F., Certal, A.C., Cristovão, A.M., Saúde, L. (2017) Foxj1a is expressed in ependymal precursors, controls central canal position and is activated in new ependymal cells during regeneration in zebrafish. Open Biology. 7(11)
Dutta, S., Sriskanda, S., Boobalan, E., Alur, R.P., Elkahloun, A., Brooks, B.P. (2015) nlz1 Is required for cilia formation in zebrafish embryogenesis. Developmental Biology. 406(2):203-11
Lu, H., Toh, M.T., Narasimhan, V., Thamilselvam, S.K., Choksi, S.P., Roy, S. (2015) A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Developmental Biology. 397(2):225-36
Yu, X., Ng, C.P., Habacher, H., and Roy, S. (2008) Foxj1 transcription factors are master regulators of the motile ciliogenic program. Nature Genetics. 40(12):1445-1453

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