ZFIN Morpholino: MO2-fezf2

Target Location

Genome Build: GRCz11Chromosome: 11

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-fezf2

Expressed Gene	Anatomy	Figures
emx2	hypothalamus postero-ventral region	Fig. 2 from Wolf et al., 2013
eomesa	diencephalon telencephalon	Fig. 5 from Chen et al., 2011
fgf8a	hypothalamus posterior region	Fig. 2 from Wolf et al., 2013
foxb1a	hypothalamus posterior region	Fig. 2 , Fig. 5 from Wolf et al., 2013
lhx2b	forebrain hindbrain	Fig. 5 from Chen et al., 2011

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Phenotype

Phenotype resulting from MO2-fezf2

Phenotype	Fish	Figures
commissural neuron axon guidance disrupted, abnormal	WT + MO2-fezf2	Fig. 5 from Chen et al., 2011
dorsal telencephalon neuronal stem cell proliferative, abnormal	s2503Tg + MO2-fezf2	Fig. 3 from Berberoglu et al., 2014
ventral thalamus decreased size, abnormal	WT + MO2-fezf2	Fig. 2 from Wolf et al., 2013

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Phenotype of all Fish created by or utilizing MO2-fezf2

Phenotype	Fish	Conditions	Figures
caudal tuberculum physical object quality, abnormal	fezf2^m808/m808 + MO2-fezf2 + MO3-fezf2	standard conditions	Fig. 3 from Blechman et al., 2007
preoptic area physical object quality, abnormal	fezf2^m808/m808 + MO2-fezf2 + MO3-fezf2	standard conditions	Fig. 3 from Blechman et al., 2007
hypothalamus physical object quality, abnormal	fezf2^m808/m808 + MO2-fezf2 + MO3-fezf2	standard conditions	Fig. 3 from Blechman et al., 2007
commissural neuron axon guidance disrupted, abnormal	WT + MO2-fezf2	standard conditions	Fig. 5 from Chen et al., 2011
ventral thalamus decreased size, abnormal	WT + MO2-fezf2	standard conditions	Fig. 2 from Wolf et al., 2013

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Citations

Include unpublished citations

Berberoglu, M.A., Dong, Z., Li, G., Zheng, J., Trejo Martinez, L.d.e.l. .C., Peng, J., Wagle, M., Reichholf, B., Petritsch, C., Li, H., Pleasure, S.J., Guo, S. (2014) Heterogeneously Expressed fezf2 Patterns Gradient Notch Activity in Balancing the Quiescence, Proliferation, and Differentiation of Adult Neural Stem Cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:13911-23
Wolf, A., and Ryu, S. (2013) Specification of posterior hypothalamic neurons requires coordinated activities of Fezf2, Otp, Sim1a and Foxb1.2. Development (Cambridge, England). 140(8):1762-1773
Yang, N., Dong, Z., and Guo, S. (2012) Fezf2 Regulates Multilineage Neuronal Differentiation through Activating Basic Helix-Loop-Helix and Homeodomain Genes in the Zebrafish Ventral Forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(32):10940-10948
Chen, L., Zheng, J., Yang, N., Li, H., and Guo, S. (2011) Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. The Journal of biological chemistry. 286(21):18641-18649
Blechman, J., Borodovsky, N., Eisenberg, M., Nabel-Rosen, H., Grimm, J., and Levkowitz, G. (2007) Specification of hypothalamic neurons by dual regulation of the homeodomain protein Orthopedia. Development (Cambridge, England). 134(24):4417-4426
Jeong, J.Y., Einhorn, Z., Mathur, P., Chen, L., Lee, S., Kawakami, K., and Guo, S. (2007) Patterning the zebrafish diencephalon by the conserved zinc-finger protein Fezl. Development (Cambridge, England). 134(1):127-136
Jeong, J.Y., Einhorn, Z., Mercurio, S., Lee, S., Lau, B., Mione, M., Wilson, S.W., and Guo, S. (2006) Neurogenin1 is a determinant of zebrafish basal forebrain dopaminergic neurons and is regulated by the conserved zinc finger protein Tof/Fezl. Proceedings of the National Academy of Sciences of the United States of America. 103(13):5143-5148

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