Gene
vip
- ID
- ZDB-GENE-080204-3
- Name
- vasoactive intestinal peptide
- Symbol
- vip Nomenclature History
- Previous Names
-
- PHI (1)
- zgc:171463
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables hormone activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including brain; eye; gut; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glucagon/GIP/secretin/VIP | VIP/GHRH-like |
|---|---|---|---|
|
UniProtKB:B8JIU2
|
153 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-9B4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:171463 | ZFIN Curated Data |
1 - 2 of 2
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114553 (1) | 1111 nt | ||
| Genomic | GenBank:CR847786 (2) | 85202 nt | ||
| Polypeptide | UniProtKB:B8JIU2 (1) | 153 aa |
- Lee, A., Kim, S.Y., Kang, S., Kang, S.H., Kim, D.W., Choe, J.W., Hyun, J.J., Jung, S.W., Jung, Y.K., Koo, J.S., Yim, H.J., Kim, S. (2024) Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish (Danio rerio) Larvae. International Journal of Molecular Sciences. 25(7):
- Yu, Y., Tanaka, S., Wong, T.T., Zohar, Y., Zmora, N. (2024) Loss of function of Vasoactive-intestinal peptide alters sex ratio and reduces male reproductive fitness in zebrafish. Endocrinology. 165(8):
- Tanaka, S., Zmora, N., Levavi-Sivan, B., Zohar, Y. (2022) Vasoactive intestinal peptide indirectly elicits pituitary LH secretion independent of GnRH in female zebrafish. Endocrinology. 163(2):
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Lovett-Barron, M., Chen, R., Bradbury, S., Andalman, A.S., Wagle, M., Guo, S., Deisseroth, K. (2020) Multiple convergent hypothalamus-brainstem circuits drive defensive behavior. Nature Neuroscience. 23(8):959-967
- Schredelseker, T., Veit, F., Dorsky, R.I., Driever, W. (2020) Bsx Is Essential for Differentiation of Multiple Neuromodulatory Cell Populations in the Secondary Prosencephalon. Frontiers in neuroscience. 14:525
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Chen, S., Reichert, S., Singh, C., Oikonomou, G., Rihel, J., Prober, D.A. (2017) Light-Dependent Regulation of Sleep and Wake States by Prokineticin 2 in Zebrafish. Neuron. 95(1):153-168.e6
- Eneman, B., Elmonem, M.A., van den Heuvel, L.P., Khodaparast, L., Khodaparast, L., van Geet, C., Freson, K., Levtchenko, E. (2017) Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome. PLoS One. 12:e0182100
- Van Camp, K.A., Baggerman, G., Blust, R., Husson, S.J. (2017) Peptidomics of the zebrafish Danio rerio: In search for neuropeptides. Journal of proteomics. 150:290-296
1 - 10 of 22
Show