ZFIN Image: Liu et al., 2022, Figure 2

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Figure Caption

Figure 2 pomt2 mutant zebrafish exhibit hydrocephalus, hypoplasia of the cerebellum, and muscular dystrophy. Sections of the brain and skeletal muscle were stained with H&E. (A,B) Lateral view of a wild-type and a pomt2 mutant zebrafish both dead 3 weeks post fertilization. Note the domed head in the mutant (arrow). (C,D) H&E staining of the rostral region of the optic tectum in zebrafish at 2-mpf. Note pomt2 mutant zebrafish showing an enlarged tectal ventricle (asterisk in (D)). (E) Ratio of ventricular area to total brain cross-sectional area. Note the increased ratio in the mutant. (F,G) H&E staining of the caudal region of the optic tectum in zebrafish at 2-mpf. Homozygous pomt2^sny5+13 mutant exhibited hypoplasia of the cerebellum (arrow). (H,I) H&E of skeletal muscle at 2-mpf. Note presence of dystrophic myofibers including necrotic fibers (asterisks), centrally located nuclei (arrowhead), and variably sized fibers. Scale bar in I: 50 µm for (C,D), 60 µm for (F,G), 28 µm for (H,I). Abbreviations: TeO = tectum opticum; PGZ = periventricular gray zone; TeV = tectal ventricle; Val = valvular cerebellum.

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Mol. Sci.