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Fig. 1
FGF signalling is required for ossification and osteoblast maturation.
(A-D) Continuous inhibition of FGF signalling from 48hpf to 120hpf in hs:dnfgfr1 larvae results in loss of ossification (B) but cartilage formation is relatively unaffected (D). (E-H) Expression of mature osteoblast markers col1a2 and col10a1 is severely reduced in hs:dnfgfr1 larvae (F,H). High magnification images of the opercle are shown to the right of panels E-H. Abbreviations: bs = branchiostegal ray, cl = cleithrum, op = opercle. Scale bar = 200μM.
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