Gene
col10a1a
- ID
- ZDB-GENE-030131-8373
- Name
- collagen, type X, alpha 1a
- Symbol
- col10a1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to be an extracellular matrix structural constituent. Acts upstream of or within fin regeneration. Predicted to be located in extracellular region. Predicted to be part of collagen type IX trimer. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including fin; mesenchymal cell; osteoblast; osteoprogenitor cell; and skeletal system. Human ortholog(s) of this gene implicated in Schmid metaphyseal chondrodysplasia and osteochondrodysplasia. Orthologous to human COL10A1 (collagen type X alpha 1 chain).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 83 figures from 60 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la019933Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12685 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa23025 | Allele with one point mutation | Unknown | Missense, Premature Stop | ENU | |
| sa23026 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ulg072Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| ulg076 | Allele with one delins | Exon 2 | Unknown | CRISPR |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Schmid metaphyseal chondrodysplasia | Alliance | Metaphyseal chondrodysplasia, Schmid type | 156500 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C1q domain | Collagen superfamily | Collagen triple helix repeat | Tumour necrosis factor-like domain superfamily |
|---|---|---|---|---|---|
|
UniProtKB:A2RQR3
|
655 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
col10a1a-201
(1)
|
Ensembl | 2,639 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-266G18 | ZFIN Curated Data | |
| Encodes | EST | fa66d11 | ||
| Encodes | EST | fb10c08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001083827 (1) | 2620 nt | ||
| Genomic | GenBank:CU306817 (1) | 176617 nt | ||
| Polypeptide | UniProtKB:A2RQR3 (1) | 655 aa |
- Cotti, S., Di Biagio, C., Huysseune, A., Koppe, W., Forlino, A., Witten, P.E. (2024) Matrix first, minerals later: fine-tuned dietary phosphate increases bone formation in zebrafish. JBMR plus. 8:ziae081ziae081
- Raman, R., Antony, M., Nivelle, R., Lavergne, A., Zappia, J., Guerrero-Limón, G., Caetano da Silva, C., Kumari, P., Sojan, J.M., Degueldre, C., Bahri, M.A., Ostertag, A., Collet, C., Cohen-Solal, M., Plenevaux, A., Henrotin, Y., Renn, J., Muller, M. (2024) The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis. Biomolecules. 14(2):
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Carletti, A., Rosa, J.T., Pes, K., Borges, I., Santos, T., Barreira, L., Varela, J., Pereira, H., Cancela, M.L., Gavaia, P.J., Laizé, V. (2023) The osteogenic and mineralogenic potential of the microalgae Skeletonema costatum and Tetraselmis striata CTP4 in fish models. Cellular and molecular life sciences : CMLS. 80:310310
- Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
- Guillemyn, B., De Saffel, H., Bek, J.W., Tapaneeyaphan, P., De Clercq, A., Jarayseh, T., Debaenst, S., Willaert, A., De Rycke, R., Byers, P.H., Rosseel, T., Coucke, P., Blaumeiser, B., Syx, D., Malfait, F., Symoens, S. (2023) Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 38(11):1718-1730
- Koosha, E., Brenna, C.T.A., Ashique, A.M., Jain, N., Ovens, K., Koike, T., Kitagawa, H., Eames, B.F. (2023) Proteoglycan inhibition of canonical BMP-dependent cartilage maturation delays endochondral ossification. Development (Cambridge, England). 151(2):
- Sobah, M.L., Liongue, C., Ward, A.C. (2023) Contribution of Signal Transducer and Activator of Transcription 3 (STAT3) to Bone Development and Repair. International Journal of Molecular Sciences. 25(1):
- Bergen, D.J.M., Tong, Q., Shukla, A., Newham, E., Zethof, J., Lundberg, M., Ryan, R., Youlten, S.E., Frysz, M., Croucher, P.I., Flik, G., Richardson, R.J., Kemp, J.P., Hammond, C.L., Metz, J.R. (2022) Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology. 20:21
- Brandão, A.S., Borbinha, J., Pereira, T., Brito, P.H., Lourenço, R., Bensimon-Brito, A., Jacinto, A. (2022) A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration. eLIFE. 11
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