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Fig. S2
Inhibition of Notch signaling by DAPT treatment does not significantly affect endocardial morphogenesis while arterial-venous differentiation is perturbed.
(A-D) Endocardial kdrl (arrows, A,B) and NFATc1 (arrows, C,D) expression at the 18-somite and 24 hpf stages, respectively, is not affected in DAPT-treated embryos (B,D) compared to DMSO-treated controls (A,C). (E,F) Venous flt4 expression at 24 hpf (arrow) is expanded in DAPT treated embryos (F) compared to DMSO-treated controls (E).
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Reprinted from Developmental Biology, 361(2), Wong, K.S., Rehn, K., Palencia-Desai, S., Kohli, V., Hunter, W., Uhl, J.D., Rost, M.S., and Sumanas, S., Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish, 377-91, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.