ZFIN Image: Schneider et al., 2010, Fig. 4

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Figure Caption

Fig. 4 Asymmetric charon expression around the KV is dependent on Nkd1 and cilia function. Expression of charon in wt (A), CtrlMO^DFC (B), and Nkd1MO^DFC (C) embryos. Expression of charon in InvsMO (D), SeaMO (E), and Ift88MO (F) injected embryos. Dashed line represents embryonic midline. (G) Graph of percent of embryos displaying left-sided (white bar), no bias (shaded bar) or right-sided biased (black bar) charon expression around KV. (n) notes the sample size for each injection set. ** = p > 0.01 compared to wt using Fisher′s exact test. Nkd1MO^DFC p-value = 3.07 × 10^{- 16}; Nkd1MO^DFC+ nkd1 RNA p-value = 0.01, SeaMO p-value = 2.3 × 10^{- 11}; Ift88MO p-value = 3.5 × 10^{- 9}; InvsMO p-value = 2.11 × 10^{- 8}.

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Acknowledgments

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Reprinted from Developmental Biology, 348(1), Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C., Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning, 22-33, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.